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Marcia Carmen Haigis

from Winchester, MA
Age ~50
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Also known as:
Marcia C Haigis, Marcia Carmen Hebert, Marcia C Hebert, Maria C Haigis, Marcia Hanens
Phone and address:
16 Madison Ave, Winchester, MA 01890
(781) 729-0295
Connected to:
Deborah L Haigis, 65Jessica N Haigis, 39Anne H Haigler, 90Ayisha N Haigler, 43Boyd F Haigler, 105Carl R Haigler, 71Carol R Haigler, 76Cynthia H Haigler, 61Denee D Haigler, 52George Haigler, 64

Marcia Haigis Phones & Addresses

  • 16 Madison Ave, Winchester, MA 01890 (781) 729-0295
  • Stoneham, MA
  • Arlington, MA
  • Madison, WI
  • Portsmouth, NH
  • Sanford, ME
  • Durham, NH
  • Cambridge, MA

Resumes

Resumes

Marcia Haigis Photo 1

Marcia Haigis

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Location:
United States

Publications

Us Patents

Sirt4 Activities

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US Patent:
20110098190, Apr 28, 2011
Filed:
Aug 5, 2010
Appl. No.:
12/851225
Inventors:
Leonard P. Guarente - Newton MA, US
Marcia C. Haigis - Stoneham MA, US
International Classification:
C40B 30/04
G01N 33/573
US Classification:
506 9, 435 74
Abstract:
Methods of screening for compounds that modulate the expression or activity of Sirt4 are provided. Also provided are methods of modulating insulin secretion, treating metabolic disorders, and treating neurodegenerative disorders by modulating the expression or activity of Sirt4.

Sirt4 And Uses Thereof

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US Patent:
20110287026, Nov 24, 2011
Filed:
Sep 23, 2009
Appl. No.:
13/120463
Inventors:
Marcia Haigis - Winchester MA, US
Vincent De Boer - Utrecht, NL
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 39/395
C12Q 1/48
A61K 31/455
A61K 31/166
A61P 1/00
A61P 35/00
A61P 3/10
A61P 21/00
A61P 27/02
A61K 31/7088
A61K 31/4709
US Classification:
4241581, 514 44 A, 435 15, 514355, 514619, 514314
Abstract:
Provided herein are SIRT4 compositions and methods of use thereof. The invention provides functional information for use in the identification and design of compounds that modulate SIRT4 enzyme activity (e.g., inhibition of fatty acid oxidation, ADP ribosylation, and/or downregulation of glutamate dehydrogenase), and to the compounds identified by such methods and the research, diagnostic and therapeutic uses of such compounds.

Sirt4 Activities

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US Patent:
20130096179, Apr 18, 2013
Filed:
Oct 5, 2012
Appl. No.:
13/646148
Inventors:
Massachusetts Institute Of Technology - Cambridge MA, US
Marcia C. Haigis - Stoneham MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
C12N 15/113
US Classification:
514 44 A
Abstract:
Methods of modulating insulin secretion and treating metabolic disorders by modulating the expression or activity of Sirt4 are provided.

Methods For The Regulation Of Cellular Metabolism Through The Modulation Of Sirt3 Activity

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US Patent:
20130171125, Jul 4, 2013
Filed:
May 11, 2011
Appl. No.:
13/697708
Inventors:
Marcia C. Haigis - Winchester MA, US
Lydia Finley - Boston MA, US
Assignee:
National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DDS), U.S. Government - Bethesda MD
International Classification:
G01N 33/68
C12Q 1/68
C12N 5/09
US Classification:
424 946, 435375, 435 74, 435 612, 435 611
Abstract:
The present invention relates to methods of preventing or treating cancer and/or decreasing damage to organs or tissues exposed to hypoxic conditions through the use of agents that modulate the expression or activity of SIRT3.

Sirt4 Activities

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US Patent:
20070099830, May 3, 2007
Filed:
Apr 21, 2006
Appl. No.:
11/409170
Inventors:
Leonard Guarente - Newton MA, US
Marcia Haigis - Stoneham MA, US
International Classification:
A61K 48/00
A61K 38/17
C12Q 1/48
US Classification:
514012000, 514044000, 435015000
Abstract:
It has been discovered that Sirt4 possesses an ADP-ribosyltransferase activity. Sirt4 is localized to mitochondria, where it binds to and regulates the activity of proteins such as glutamate dehydrogenase. The ADP-ribosyltransferase activity of Sirt4 is important for the regulation of biological functions such as insulin secretion. Methods of screening for compounds that modulate the expression or activity of Sirt4 are provided. Also provided are methods of modulating insulin secretion, treating metabolic disorders, and treating neurodegenerative disorders by modulating the expression or activity of Sirt4.

Methods Of Cancer Treatment And Prevention Through The Modulation Of Sirt4 Activity

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US Patent:
20140186325, Jul 3, 2014
Filed:
Jun 7, 2012
Appl. No.:
14/125175
Inventors:
Marcia C. Haigis - Winchester MA, US
Seungmin Jeong - Brookline MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 38/45
G01N 33/574
C12Q 1/68
US Classification:
424 945, 514 44 R, 435375, 435 611, 436501
Abstract:
The present invention relates to methods of preventing or treating cancer through the use of agents that enhance the activity or expression of SIRT4.
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Marcia Carmen Haigis from Winchester, MA, age ~50 Get Report