US Patent:
20180362587, Dec 20, 2018
Inventors:
- Rochester NY, US
Lynne Maquat - Rochester NY, US
Rudi Fasan - Rochester NY, US
International Classification:
C07K 7/08
A61K 38/10
A61K 45/06
A61P 35/00
Abstract:
The invention provides compositions and methods for inhibiting protein-protein interactions with cap-binding protein 80 (CBP80). In one embodiment, the invention provides compositions comprising linear and macrocylic peptides. In one embodiment, the invention provides methods for treating cancer, heart disease, autoimmune disorders, obesity, diabetes, or chronic inflammation disorders associated with the PGC1 family of co-activators.