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Lyle W Spruce

from San Diego, CA
Age ~65
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Also known as:
Lyle Warren Spruce, Lyle D Spruce, Lylew W Spruce, Deidre Stacy Spruce
Phone and address:
11453 Larmier Cir, San Diego, CA 92131
(619) 665-1103
Related to:
Kaitlin Zieser, 27Stuart Zieser, 51Aaron ZieserCarol E Zieser, 62Steven J Zieser, 63
Connected to:
Eric Spruce, 79Jason B Spruce, 39Julie C Spruce, 56Raymond J Spruce, 74Roy C Spruce, 85Caren L Spruch, 67Robert C Spruck, 59Frank L Sprude, 55Peteris J Sprudzs, 63Amber M Spruell, 43

Lyle Spruce Phones & Addresses

  • 11453 Larmier Cir, San Diego, CA 92131 (619) 665-1103
  • 10162 Camino Ruiz, San Diego, CA 92126
  • 2102 Celia St, Stillwater, OK 74074 (405) 747-8212
  • 948 Camino Del Sol, Chula Vista, CA 91910
  • Arvada, CO
  • Denver, CO

Work

Company: Arena pharmaceuticals Position: Chairman

Skills

Medicinal Chemistry • Drug Discovery • Chemistry • Organic Synthesis • Patents • Biotechnology • Life Sciences • Organic Chemistry • Drug Development • Pharmaceutical Industry • Biopharmaceuticals • Hplc • Technology Transfer • Lc Ms • Analytical Chemistry

Industries

Pharmaceuticals

Resumes

Resumes

Lyle Spruce Photo 1

Lyle Spruce

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Location:
6166 Nancy Ridge Dr, San Diego, CA 92121
Industry:
Pharmaceuticals
Work:
Arena Pharmaceuticals
Chairman
Arena Pharmaceuticals
Director Patents , Chemistry
Arena Pharmaceuticals
Patent Agent
Skills:
Medicinal Chemistry
Drug Discovery
Chemistry
Organic Synthesis
Patents
Biotechnology
Life Sciences
Organic Chemistry
Drug Development
Pharmaceutical Industry
Biopharmaceuticals
Hplc
Technology Transfer
Lc Ms
Analytical Chemistry

Publications

Us Patents

Heterocyclic Derivatives For The Treatment Of Diabetes And Other Diseases

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US Patent:
6515003, Feb 4, 2003
Filed:
Aug 31, 2000
Appl. No.:
09/652810
Inventors:
Magnus Pfahl - Solana Beach CA
Catherine Tachdjian - San Diego CA
Hussien A. Al-Shamma - Encinitas CA
Andrea Fanjul - San Diego CA
David P. M. Pleynet - San Diego CA
Lyle W. Spruce - Chula Vista CA
Assignee:
Maxia Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07D27734
US Classification:
514369, 548183
Abstract:
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkins Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohns Disease or Inflammatory Bowel Disease.

Peptoid And Nonpeptoid Containing -Keto Oxadiazoles As Serine Protease Inhibitors

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US Patent:
6548638, Apr 15, 2003
Filed:
Apr 26, 2001
Appl. No.:
09/842543
Inventors:
Albert Gyorkos - Westminster CO
Lyle Spruce - Chula Vista CA
Kazuyuki Ohmoto - Osaka, JP
Kazuhito Kawabata - Osaka, JP
Assignee:
Cortech, Inc. - Bedminster NJ
International Classification:
A61K 3805
US Classification:
530331, 514 18, 514 19, 544319
Abstract:
The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.

Serine Protease Inhibitors

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US Patent:
6608175, Aug 19, 2003
Filed:
Nov 16, 2001
Appl. No.:
09/991286
Inventors:
Albert Gyorkos - Westminster CO
Lyle W. Spruce - Chula Vista CA
Assignee:
Cortech, Inc. - Bedminster NJ
International Classification:
C07K 102
US Classification:
530331, 530338, 530540, 540485, 540492, 540520, 540522, 546114, 546115, 548122, 548123, 548124, 548125, 548128, 548131, 548136, 548143, 5482622
Abstract:
Certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases, are prepared in various embodiments using Grignard reagents and alkyllithium reagents and various aldehydes to make oxadiazole, thiadiazole and triazole peptoid alcohols, which are then oxidized to the desired keto products.

Serine Protease Inhibitors

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US Patent:
6656910, Dec 2, 2003
Filed:
Aug 10, 2001
Appl. No.:
09/928117
Inventors:
Albert Gyorkos - Westminster CO
Lyle W. Spruce - Chula Vista CA
Assignee:
Cortech, Inc. - Bedminster NJ
International Classification:
A61K 3805
US Classification:
514 18, 514 19, 530331, 544182, 544300, 544405, 546142, 546156, 546157, 5462687, 5462691, 5462724, 548128, 548131, 548136, 548143, 548184, 548187, 548188, 5482668
Abstract:
The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, septic shock, and myocardial ischemia-reperfusion injury.

Serine Protease Inhibitors

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US Patent:
6656911, Dec 2, 2003
Filed:
Apr 18, 2002
Appl. No.:
10/125222
Inventors:
Albert Gyorkos - Westminster CO
Lyle W Spruce - Chula Vista CA
Assignee:
Cortech, Inc. - Bedminster NJ
International Classification:
A61K 3805
US Classification:
514 18, 514 19, 530331, 540488, 540524, 544 54, 544182, 544238, 544300, 544405, 546142, 546156, 546157, 5462687, 5462691, 5462724, 548128, 548131, 548136, 548143, 548184, 548187, 548188, 5482668
Abstract:
The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, septic shock, and myocardial ischemia-reperfusion injury.

Thiazolidinedione Derivatives For The Treatment Of Diabetes And Other Diseases

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US Patent:
6765013, Jul 20, 2004
Filed:
Dec 31, 2002
Appl. No.:
10/334932
Inventors:
Magnus Pfahl - Solana Beach CA
Catherine Tachdjian - San Diego CA
Hussien A. Al-Shamma - Encinitas CA
Andrea Fanjul - San Diego CA
David P. M. Pleynet - San Diego CA
Lyle W. Spruce - Chula Vista CA
Assignee:
Incyte San Diego - Wilmington DE
International Classification:
A61K 31425
US Classification:
514369, 548183
Abstract:
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkins Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohns Disease or Inflammatory Bowel Disease.

Imidazolidinedione Derivatives For The Treatment Of Diabetes And Other Diseases

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US Patent:
6974826, Dec 13, 2005
Filed:
Jul 19, 2004
Appl. No.:
10/894411
Inventors:
Magnus Pfahl - Solana Beach CA, US
Catherine Tachdjian - San Diego CA, US
Hussien A. Al-Shamma - Encinitas CA, US
Andrea Fanjul - San Diego CA, US
David P. M. Pleynet - San Diego CA, US
Lyle W. Spruce - Chula Vista CA, US
Assignee:
Incyte San Diego Inc. - Wilmington DE
Ortho McNeil Pharmaceutical Inc. - Raritan NJ
International Classification:
A61K031/44
A61K031/415
C07D261/04
C07D233/28
C07D401/00
US Classification:
514340, 514341, 514380, 514398, 548243, 5483164, 5483171, 5462744, 5462721
Abstract:
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

N-Substituted Heterocycles For The Treatment Of Hypercholesteremia, Dyslipidemia And Other Metabolic Disorders; Cancer, And Other Diseases

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US Patent:
7071218, Jul 4, 2006
Filed:
Nov 15, 2002
Appl. No.:
10/298024
Inventors:
Magnus Pfahl - Solana Beach CA, US
Catherine Tachdjian - San Diego CA, US
Lyle W. Spruce - Chula Vista CA, US
Hussien A. Al-Shamma - Encinitas CA, US
Mohamed Boudjelal - San Diego CA, US
Andrea N. Fanjul - San Diego CA, US
Torsten R. Wiemann - Encinitas CA, US
David P. M. Pleynet - San Diego CA, US
Assignee:
Incyte San Diego Incorporated - San Diego CA
Ortho McNeil Pharmaceutical Inc. - Rariton NJ
International Classification:
A61K 31/426
C07D 277/36
C07D 401/02
US Classification:
514342, 514369, 548183, 548226, 5483171
Abstract:
The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia:.
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Lyle W Spruce from San Diego, CA, age ~65 Get Report