Inventors:
Ramnarayan S. Randad - Frederick MD
John W. Erickson - Frederick MD
Michael A. Eissenstat - Frederick MD
Lucyna Lubkowska - Frederick MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 315377
US Classification:
5142358, 514256, 514318, 544123, 544129, 544316
Abstract:
The present invention provides a compound of formula (I) wherein a, b, c, d, and e, are R , OR , SR , NR R , NHCOR , CO R , CN, NO , NH , N , or a halogen. R and R are H or alkyl, R and R are H or alkyl, and R is a non-aromatic substituent. Substituent A is OH, NH , or SH. Substituents B and B include amide and sulfonamide groups, which can be cyclic, acyclic, or amino acid derivatives. Alternatively, B and Râ together with the nitrogen to which they are bonded, and/or Bâ and R together with the nitrogen to which they are bonded, define a heterocycle. The present invention further provides a pharmaceutical composition that includes a carrier and a therapeutically effective amount of at least one compound of the present invention. The present invention further provides therapeutic methods that include administering a therapeutically effective amount of at least one compound of the present invention.