Resumes
Resumes
Lizbeth Hedstrom Phones & Addresses
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25 Lewis St, Newton, MA 02158 (617) 771-9919
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27 Lewis St, Newton, MA 02458 (617) 630-9285
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Auburndale, MA
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Frederick, MD
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Waltham, MA
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San Francisco, CA
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27 Lewis St, Newton, MA 02458 (617) 771-9919
Work
Position:
Service Occupations
Education
Degree:
Associate degree or higher
Publications
Us Patents
Compounds And Methods For Treating Mammalian Gastrointestinal Microbial Infections
View pageUS Patent:
20120101096, Apr 26, 2012
Filed:
Mar 22, 2010
Appl. No.:
13/257418
Inventors:
Lizbeth K. Hedstrom - Newton MA, US
Gregory D. Cuny - Somerville MA, US
Deviprasad R. Gollapalli - Waltham MA, US
Sivapriya Kirubakaran - Chennai, IN
Sushil Kumar Maurya - Leeds, GB
Boris Striepen - Athens GA, US
Suresh Kumar Gorla - Waltham MA, US
Corey Robert Johnson - Waltham MA, US
Mandapati Kavitha - Waltham MA, US
Jihan Khan - Somerville MA, US
Gregory D. Cuny - Somerville MA, US
Deviprasad R. Gollapalli - Waltham MA, US
Sivapriya Kirubakaran - Chennai, IN
Sushil Kumar Maurya - Leeds, GB
Boris Striepen - Athens GA, US
Suresh Kumar Gorla - Waltham MA, US
Corey Robert Johnson - Waltham MA, US
Mandapati Kavitha - Waltham MA, US
Jihan Khan - Somerville MA, US
Assignee:
University of Georgia Foundation, Inc. - Athens GA
Brandeis University - Waltham MA
Brandeis University - Waltham MA
International Classification:
A61K 31/535
US Classification:
5142345
Abstract:
Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
Compounds And Methods For Treating Mammalian Gastrointestinal Parasitic Infections
View pageUS Patent:
20120264760, Oct 18, 2012
Filed:
Jun 6, 2012
Appl. No.:
13/490002
Inventors:
Lizbeth K. Hedstrom - Newton MA, US
Boris Striepen - Athens GA, US
Boris Striepen - Athens GA, US
Assignee:
University of Georgia Research Foundation, Inc. - Athens GA
Brandeis University - Waltham MA
Brandeis University - Waltham MA
International Classification:
A61K 31/167
C07C 233/29
C07D 417/04
A61K 31/427
C07D 237/32
A61K 31/502
C07D 215/50
A61K 31/4704
C07D 495/04
A61K 31/519
C07D 235/02
A61K 31/4184
C07D 241/52
A61K 31/498
C07D 405/12
A61K 31/4433
C07C 237/20
C07D 213/75
A61P 33/02
A61P 33/04
A61K 31/4409
C07C 217/84
A61K 31/137
C07C 233/75
C07C 235/24
C07C 233/29
C07D 417/04
A61K 31/427
C07D 237/32
A61K 31/502
C07D 215/50
A61K 31/4704
C07D 495/04
A61K 31/519
C07D 235/02
A61K 31/4184
C07D 241/52
A61K 31/498
C07D 405/12
A61K 31/4433
C07C 237/20
C07D 213/75
A61P 33/02
A61P 33/04
A61K 31/4409
C07C 217/84
A61K 31/137
C07C 233/75
C07C 235/24
US Classification:
514249, 564175, 514622, 564180, 514617, 548181, 514365, 544237, 514248, 546156, 514312, 544278, 5142601, 5483021, 514394, 544354, 5462824, 514338, 514620, 564164, 546309, 514395, 514352, 564378, 514654
Abstract:
One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
Methods For The Development Of Vaccines Based On Oligosaccharide-Oligonucleotide Conjugates
View pageUS Patent:
20130116417, May 9, 2013
Filed:
Jun 10, 2011
Appl. No.:
13/701849
Inventors:
Isaac J. Krauss - Waltham MA, US
Lizbeth K. Hedstrom - Newton MA, US
Iain S. MacPherson - Honolulu HI, US
Lizbeth K. Hedstrom - Newton MA, US
Iain S. MacPherson - Honolulu HI, US
Assignee:
BRANDEIS UNIVERSITY - WALTHAM MA
International Classification:
C12N 15/10
C07H 15/22
C07H 21/04
C07H 15/22
C07H 21/04
US Classification:
536 174, 435 915, 506 1, 536 179
Abstract:
Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative.
Small-Molecule-Targeted Protein Degradation
View pageUS Patent:
20130190340, Jul 25, 2013
Filed:
Jun 30, 2011
Appl. No.:
13/805508
Inventors:
Lizbeth K. Hedstrom - Newton MA, US
Marcus Long - Somerville MA, US
Deviprasad R. Gollapalli - Waltham MA, US
Marcus Long - Somerville MA, US
Deviprasad R. Gollapalli - Waltham MA, US
Assignee:
Brandeis University - Walthan MA
International Classification:
C07C 279/14
C07C 211/12
C07C 65/40
C07D 239/49
C07D 271/12
C07C 211/12
C07C 65/40
C07D 239/49
C07D 271/12
US Classification:
514275, 514364, 514565, 514570, 514616, 514673, 544325, 548125, 562439, 562471, 564157, 564511
Abstract:
Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other aspects, said compounds can be useful research tools for investigating protein degradation. In other aspects, said compounds are useful research tools for investigating protein function. In certain embodiments, the degraded protein is implicated in a disease or disorder whose pathology is related at least in part to the excessive expression of the protein or the expression of a mutant form of the protein.
Compounds And Methods For Treating Mammalian Gastrointestinal Parasitic Infections
View pageUS Patent:
20100022547, Jan 28, 2010
Filed:
Jun 1, 2007
Appl. No.:
12/302600
Inventors:
Lizbeth K. Hedstrom - Newton MA, US
Boris Striepen - Athens GA, US
Boris Striepen - Athens GA, US
Assignee:
BRANDEIS UNIVERSITY - WALTHAM MA
UNIVERSITY OF GEORFIA RESEARCH FOUNDATION - ATHENS GA
UNIVERSITY OF GEORFIA RESEARCH FOUNDATION - ATHENS GA
International Classification:
A61K 31/498
A61K 31/165
C07C 233/01
A61K 31/426
C07D 277/20
A61K 31/502
C07D 237/30
A61K 31/47
C07D 215/00
A61K 31/519
C07D 495/02
A61K 31/4184
C07D 235/02
C07D 241/36
A61K 31/4433
C07D 405/02
A61P 33/02
A61K 31/165
C07C 233/01
A61K 31/426
C07D 277/20
A61K 31/502
C07D 237/30
A61K 31/47
C07D 215/00
A61K 31/519
C07D 495/02
A61K 31/4184
C07D 235/02
C07D 241/36
A61K 31/4433
C07D 405/02
A61P 33/02
US Classification:
514249, 514622, 564175, 514617, 564180, 514365, 548202, 514248, 544237, 514312, 546156, 5142601, 544278, 514393, 5483021, 544354, 514338, 5462824
Abstract:
One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
Mtor Inhibitors And Methods Of Use Thereof
View pageUS Patent:
20180327364, Nov 15, 2018
Filed:
Nov 14, 2016
Appl. No.:
15/774962
Inventors:
- Waltham MA, US
Jianjun Xue - Newton MA, US
Lizbeth K. Hedstrom - Auburndale MA, US
Rory T. Coffey - Brighton MA, US
Jianjun Xue - Newton MA, US
Lizbeth K. Hedstrom - Auburndale MA, US
Rory T. Coffey - Brighton MA, US
International Classification:
C07D 239/49
C07C 279/24
C07C 271/20
C07C 279/30
A61P 35/00
C07C 279/24
C07C 271/20
C07C 279/30
A61P 35/00
Abstract:
Disclosed are small molecule inhibitors of mammalian target of rapamycin (mTOR), and methods of using them.
Methods For The Development Of Vaccines Based On Oligosaccharide-Oligonucleotide Conjugates
View pageUS Patent:
20160051690, Feb 25, 2016
Filed:
Jun 19, 2015
Appl. No.:
14/744985
Inventors:
- Waltham MA, US
Lizbeth K. HEDSTROM - Newton MA, US
Iain S. MACPHERSON - Honolulu HI, US
Lizbeth K. HEDSTROM - Newton MA, US
Iain S. MACPHERSON - Honolulu HI, US
International Classification:
A61K 47/48
C12N 7/00
A61K 39/21
C12N 7/00
A61K 39/21
Abstract:
Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative screening process.