Lisa K Liu

20230065628, Mar 2, 2023

Feb 19, 2021

17/759592

- Boston MA, US
Paul Brown - Boston MA, US
Chase Spenser Coffman - Newton MA, US
James W. Ivey - Reading MA, US
Lisa Liu - Somerville MA, US
Shankul Vartak - Cambridge MA, US

A61K 9/16
C07K 16/28

The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic biologies.

20210322317, Oct 21, 2021

Jun 30, 2021

17/364770

- Boston MA, US
Paul Brown - Boston MA, US
Daniel Benjamin Dadon - East Boston MA, US
Lisa Liu - Somerville MA, US
Cory Robinson - Cambridge MA, US

A61K 9/14
B01J 2/06

The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

20210315827, Oct 14, 2021

Jun 18, 2021

17/351937

- Boston MA, US
Chase Spenser Coffman - Newton MA, US
Daniel Benjamin Dadon - East Boston MA, US
James Ivey - Somerville MA, US
Lisa Liu - Somerville MA, US
Chaitanya Sudrik - Stoneham MA, US

A61K 9/51
C07K 16/00

The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

20210220289, Jul 22, 2021

May 24, 2019

17/058339

- Boston MA, US
Lyndon CHARLES, Jr. - Medford MA, US
Paul BROWN - Boston MA, US
Daniel Benjamin DADON - East Boston MA, US
Lisa LIU - Somerville MA, US
Sadiqua SHADBAR - Allston MA, US
Chaitanya SUDRIK - Cambridge MA, US

A61K 9/51
A61K 47/02
A61K 47/26
A61K 47/14
A61K 47/18
A61K 31/167
A61K 45/06

The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

20200253875, Aug 13, 2020

Jul 25, 2018

16/633097

- Boston MA, US
Paul Brown - Boston MA, US
Daniel Benjamin Dadon - Cambridge MA, US
Lisa Liu - Cambridge MA, US
Cory Robinson - Cambridge MA, US

A61K 9/14
B01J 2/06

The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

20190374470, Dec 12, 2019

Nov 22, 2017

16/463238

- Boston MA, US
Lyndon CHARLES - Medford MA, US
Paul BROWN - Boston MA, US
Daniel Benjamin DADON - Cambridge MA, US
Lisa LIU - Somerville MA, US
Cory ROBINSON - Cambridge MA, US

A61K 9/16
A61K 39/395
B05B 5/025

The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

20180225052, Aug 9, 2018

Feb 9, 2017

15/428455

- Houston TX, US
Lisa Liu - Fremont CA, US
Sujatha Mudupalli - Fremont CA, US

G06F 3/06

An example method of controlling a storage system that includes a replication group. The method may include adding a virtual volume to the replication group by storing a journal entry for the virtual volume at a source site. The journal entry may include: metadata for hooking the virtual volume to a corresponding replica volume; and data indicating a status of the virtual volume. The method may further include sending a message to a replica site instructing it to create the corresponding replica volume for the virtual volume and store a replica journal entry for the replica volume. The method may also include determining whether to set the status of the virtual volume to pending admittance or newly admitted based on whether the replica site was able to successfully create the replica volume and store the replica journal entry. The pending admittance status may indicate that the virtual volume is not to be included in a next synchronize operation and the newly admitted status may indicate that the virtual volume is to be included in the next synchronize operation.