Linda L Setescak

45607010, Dec 24, 1985

Jun 13, 1983

6/503456

Lawrence L. Martin - Lebanon NJ
Linda L. Setescak - Somerville NJ

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

A61K 3138
C07D32704
C07D49502
C07D33338

514443

The invention relates to oxothienobenzoxepin compounds of the formula ##STR1## where X together with the carbon atoms to which it is attached is a thiophene ring; R. sub. 1 is hydrogen, a straight or branched chain alkyl group having 1 to 5 carbon atoms or a halogen atom; R. sub. 2 is hydrogen or a straight chain alkyl group having 1 to 5 carbon atoms; and R. sub. 3 is hydroxyl or ##STR2## where R. sub. 4 is a straight chain or branched chain alkyl group having 1 to 10 carbon atoms, a phenyl group or a trifluoromethyl group. Methods for preparing the compounds and their use as antiinflammatory and analgesic agents are provided.

45268916, Jul 2, 1985

Mar 10, 1983

6/474106

Lawrence L. Martin - Lebanon NJ
Linda L. Setescak - Somerville NJ

Hoechst Roussel Pharmaceuticals Inc. - Somerville NJ

A61K 31495
C07D40506

514253

This invention relates to compounds of the formula: ##STR1## where X is hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF. sub. 3 ; R is H, and lower alkyl, R. sub. 1 is CH. sub. 3 SO. sub. 3 and ##STR2## where R. sub. 2 and R. sub. 3 are the same or different and are hydrogen, lower alkyl, mesyl (CH. sub. 3 SO. sub. 2 --), and cycloalkyl loweralkyl; ##STR3##.

50082850, Apr 16, 1991

Nov 1, 1989

7/430045

Lawrence L. Martin - Lebanon NJ
Linda L. Setescak - Somerville NJ

Hoechst-Roussel Pharmaceuticals, Inc. - Somerville NJ

A61K 31335
C07D31312

514450

Novel (6,11-dihydro-11-oxodibenz[b,e]oxepinyl)pentanoic acids and derivatives thereof, intermediates and processes for the preparation thereof, and methods for suppressing arthritis-like inflammation utilizing compounds or compositions thereof are disclosed.

47286628, Mar 1, 1988

Feb 9, 1987

7/016293

Gregory M. Shutske - Nauheim, DE
Linda L. Setescak - Somerville NJ
Richard C. Allen - Flemington NJ

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

A61K 3142
A61K 3144
A61K 31425

514379

Novel 1,2-benzisoxazoloxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretic, uricosuric and antihypertensive agents.

44879342, Dec 11, 1984

Jun 6, 1980

6/157916

Gregory M. Shutske - Somerset NJ
Linda L. Setescak - Somerville NJ

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

C07D21356
C07D30932
C07C 4980

546314

A method of preparing substituted acylbenzenes is disclosed. The method comprises reacting selected acylhalides or equivalents with a selected poly-substituted benzene in the presence of an acylating catalyst comprising a perfluoro sulfonic acid polymer.

43372619, Jun 29, 1982

Jul 28, 1980

6/173203

Gregory M. Shutske - Somerset NJ
Linda L. Setescak - Somerville NJ
Richard C. Allen - Flemington NJ

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

A61K 3142
C07D26120

424272

Novel (1,2-benzisoxazol)phenoxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretics.

45144117, Apr 30, 1985

Aug 10, 1984

6/639548

Lawrence L. Martin - Lebanon NJ
Linda L. Setescak - Somerville NJ

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

A61K 3142
C07D49504

514215

This invention relates to substituted 4,10-dihydro-10-oxothieno benzoxepins of the formula, ##STR1## where R is hydrogen and lower alkyl; R. sub. 1 is ##STR2## where R. sub. 2 is hydrogen, lower alkyl and benzyl of the formula ##STR3## where X is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, nitro, and amino; ##STR4## where R. sub. 3 and R. sub. 4 are the same or different and are hydrogen and lower alkyl; ##STR5## where R. sub. 5 and R. sub. 6 are the same or different and are lower alkyl; and the pharmaceutically acceptable acid addition salts thereof.

44774656, Oct 16, 1984

Mar 10, 1983

6/474218

Lawrence L. Martin - Lebanon NJ
Linda L. Setescak - Somerville NJ

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

A61K 3138
C07D49504

424275

This invention relates to substituted 4,10-dihydro-10-oxothieno benzoxepins of the formula, ##STR1## where R is hydrogen and lower alkyl; R. sub. 1 is ##STR2## where R. sub. 2 is hydrogen, lower alkyl and benzyl of the formula ##STR3## where X is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, nitro, and amino; ##STR4## where R. sub. 3 and R. sub. 4 are the same or different and are hydrogen and lower alkyl; ##STR5## where R. sub. 5 and R. sub. 6 are the same or different and are lower alkyl; and the pharmaceutically acceptable acid addition salts thereof.