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Liangxing Wu

from Berkeley, CA
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Also known as:
Liang Wu
Related to:
Wei Wu, 54Kangcong Wu, 64
Connected to:
Aihua Wu, 39Ailsa T Wu, 53Alice H Wu, 54Alix S Wu, 51Amie Wu, 39Angela Y Wu, 71Anqi Wu, 44Anqiang Wu, 47Banting H Wu, 62Baodong Wu, 61

Liangxing Wu Phones & Addresses

  • Berkeley, CA
  • Torrance, CA
  • Wilmington, DE

Publications

Us Patents

Pyrazolyl Bicyclic Amines As Cdk2 Inhibitors

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US Patent:
20220340579, Oct 27, 2022
Filed:
Apr 12, 2022
Appl. No.:
17/719131
Inventors:
- Wilmington DE, US
David M. Burns - Plymouth Meeting PA, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
International Classification:
C07D 487/04
A61P 35/00
Abstract:
The present application provides pyrazolyl bicyclic amines of Formula (I):and their pharmaceutically acceptable salts thereof, that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Pyrido[3,2-D]Pyrimidine Compounds As Immunomodulators

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US Patent:
20220340600, Oct 27, 2022
Filed:
Jun 27, 2022
Appl. No.:
17/850505
Inventors:
- Wilmington DE, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
International Classification:
C07D 519/00
Abstract:
The present disclosure is directed to compounds of Formula (I):which modulate PD-1/PD-L1 protein/protein interaction, compositions, and methods of treating various diseases, including infectious diseases and cancer.

Imidazopyridazine And Imidazopyridine Compounds And Uses Thereof

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US Patent:
20220315595, Oct 6, 2022
Filed:
Jun 9, 2022
Appl. No.:
17/836602
Inventors:
- Wilmington DE, US
Jeremy Roach - Philadelphia PA, US
Song Mei - Wilmington DE, US
Chunhong He - Boothwyn PA, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
International Classification:
C07D 487/04
C07D 519/00
Abstract:
Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Spirocyclic Lactams As Jak2 V617F Inhibitors

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US Patent:
20220281887, Sep 8, 2022
Filed:
Feb 24, 2022
Appl. No.:
17/680002
Inventors:
- Wilmington DE, US
Charles Cole - Wilmington DE, US
Nikoo Falahatpisheh - Wilmington DE, US
Kai Liu - Chadds Ford PA, US
Lixin Shao - Wilmington DE, US
Darius Vrubliauskas - Wilmington DE, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Eddy W. Yue - Landenberg PA, US
International Classification:
C07D 491/22
C07D 471/22
C07D 471/20
C07D 471/18
C07D 519/00
A61P 35/00
Abstract:
The present application provides spirocyclic lactam compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Combination Therapy Comprising A2A/A2B Inhibitors, Pd-1/Pd-L1 Inhibitors, And Anti-Cd73 Antibodies

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US Patent:
20220233529, Jul 28, 2022
Filed:
Dec 29, 2021
Appl. No.:
17/564549
Inventors:
- Wilmington DE, US
Juan Carlos Almagro - Cambridge MA, US
Rebecca A. Buonpane - Wilmington DE, US
Peter Niels Carlsen - Claymont DE, US
Taisheng Huang - Wilmington DE, US
Yong Li - Newark DE, US
Horacio G. Nastri - West Chester PA, US
Chao Qi - Newark DE, US
Shaun M. Stewart - Chadds Ford PA, US
Xiaozhao Wang - Mt. Laurel NJ, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Jing Zhou - Boxborough MA, US
Wenyu Zhu - Media PA, US
International Classification:
A61K 31/501
A61P 35/00
A61K 39/395
C07K 16/28
Abstract:
Disclosed are combination therapies comprising administration of a CD73 inhibitor, an adenosine A2A or A2B receptor inhibitor, and a PD-1/PD-L1 inhibitor. The disclosed combination therapies are useful in the treatment of diseases related to the activity of adenosine receptors and/or CD73 and/or PD-1/PD-L1 including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. Anti-CD73 antibodies, PD-1/PD-L1 inhibitors, and A2A/A2B inhibitors are also disclosed.

Deazaguaine Compounds As Jak2 V617F Inhibitors

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US Patent:
20220213108, Jul 7, 2022
Filed:
Dec 20, 2021
Appl. No.:
17/555768
Inventors:
- Wilmington DE, US
Onur Atasoylu - Wilmington DE, US
Cheng-Tsung Lai - Wilmington DE, US
Padmaja Polam - Kennett Square PA, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
International Classification:
C07D 487/04
Abstract:
The present application provides deazaguaine compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Heterocyclic Compounds As Immunomodulators

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US Patent:
20230100875, Mar 30, 2023
Filed:
Nov 22, 2022
Appl. No.:
17/992399
Inventors:
- Wilmington DE, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
International Classification:
C07D 471/04
C07D 215/40
Abstract:
Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

Imidazolyl Pyrimidinylamine Compounds As Cdk2 Inhibitors

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US Patent:
20230024173, Jan 26, 2023
Filed:
Jul 29, 2022
Appl. No.:
17/816271
Inventors:
- Wilmington DE, US
Jingwei Li - Westfield NJ, US
Ken Mukai - Wilmington DE, US
Brandon Smith - Chadds Ford PA, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Min Ye - Garnet Valley PA, US
Yingnan Chen - Wilmington DE, US
Margaret Favata - North East MD, US
Yvonne Lo - Hockessin DE, US
International Classification:
C07D 401/14
A61P 35/00
C07D 405/14
C07D 413/14
C07D 471/08
C07D 471/10
C07D 498/08
Abstract:
The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
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Liangxing Wu from Berkeley, CA Get Report