Li Guo

7820858, Oct 26, 2010

Mar 26, 2007

11/691249

Yonggui Chi - Berkeley CA, US
Samuel H. Gellman - Madison WI, US
William C. Pomerantz - Madison WI, US
William S. Horne - Madison WI, US
Li Guo - Madison WI, US
Emily P. English - Madison WI, US

Wisconsin Alumni Research Foundation - Madison WI

C07C 213/00
C07C 215/28
C07C 271/22
C07C 269/06
C07C 217/64
C07D 209/14
C07D 209/26

562553, 562531

The present invention provides a method for the synthesis of β-amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of β-amino acids.

8269039, Sep 18, 2012

Mar 23, 2009

12/383370

Samuel Helmer Gellman - Madison WI, US
Yonggui Chi - Berkeley CA, US
Li Guo - Madison WI, US

Wisconsin Alumni Research Foundation - Madison WI

C07C 205/51
C07C 205/44

562571, 562553, 562434, 568423, 568704

The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide α-substituted-γ-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e. g. , 96-99% e. e. ). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected γ-amino acids, which are essential for systematic conformational studies of γ-peptide foldamers.

8637696, Jan 28, 2014

Sep 17, 2012

13/621553

Samuel Helmer Gellman - Madison WI, US
Yonggui Chi - Berkeley CA, US
Li Guo - Madison WI, US

Wisconsin Alumni Research Foundation - Madison WI

C07C 231/04
C07C 269/04
C07C 227/12
C07C 271/22
C07C 227/02
C07C 269/00

560 24, 560 41, 560157, 562526

The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide α-substituted-γ-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e. g. , 96-99% e. e. ). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected γ-amino acids, which are essential for systematic conformational studies of γ-peptide foldamers.

20110118440, May 19, 2011

Oct 14, 2010

12/904942

Samuel Helmer Gellman - Madison WI, US
Li Guo - Blue Bell PA, US
Michael Giuliano - Madison WI, US

C07K 7/06
C07C 229/46
C07K 5/08

530330, 560125, 562507, 530331

The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline derivative to provide cyclically constrained α-substituted-γ-nitro-aldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96 to >99% e.e.).The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to cyclically constrained protected γ-amino acid residues, which are essential for systematic conformational studies of γ-peptide foldamers. New methods are also provided to prepare other γ-amino acids and peptides. These new building blocks can be used to prepare foldamers, such as α/γ-peptide foldamers, that adopt specific helical conformations in solution and in the solid state.

20130062049, Mar 14, 2013

Sep 12, 2011

13/229923

Jiaxiang Ren - Houston TX, US
David P. Gerrard - Magnolia TX, US
James E. Goodson - Porter TX, US
Li Guo - Houston TX, US
Ping Duan - Cypress TX, US

BAKER HUGHES INCORPORATED - Houston TX

E21B 33/12
B29C 44/12

166101, 264 453

A downhole element to isolate or complete a wellbore includes a shape memory material including polyphenylene sulfide. The polyphenylene sulfide is the cure product of being cured at a temperature of about 200 C. to about 400 C., for a total time of less than or equal to 200 hours. The shape memory material is thermally activated between an actuated and unactuated shape, and the polyphenylene sulfide in the shape memory material is a closed cell foam, open cell foam, or solid.

20220364559, Nov 17, 2022

May 14, 2020

17/595287

- Sugar Land TX, US
Maxim Pushkarev - Edmonton, CA
Samba Ba - Beijing, CN
Li Guo - Katy TX, US
Robert Little - Katy TX, US
Geoffrey Charles Downton - Stonehouse, GB

F04C 2/107
F04C 13/00

A mud motor includes a rotor and a stator. Drilling fluid received by cavities of the mud motor drives the rotor to rotate within the stator. The rotor includes one or more rotor lobes extending helically and defining a rotor pitch. The stator includes two or more stator lobes extending helically and defining a stator pitch. The rotor and the stator together define a tapered profile of the mud motor that varies proceeding from a top end of the mud motor to a bottom end of the mud motor. At least one of the rotor pitch or the stator pitch vary as proceeding from the top end of the mud motor to the bottom end of the mud motor.

20230127027, Apr 27, 2023

Dec 22, 2022

18/086856

- Houston TX, US
Li Guo - Humble TX, US

C09K 8/28
B01D 17/02
B01D 17/04

A method may include: performing a treatment operation on at least a portion of a subterranean formation using an oil-in-water emulsion treatment fluid that comprises an oleaginous phase and an aqueous phase; recovering at least a portion of the oil-in-water emulsion treatment fluid from the portion of the subterranean formation; introducing a quaternary ammonium compound into the recovered portion of the oil-in-water emulsion treatment fluid at a well site; and mechanically separating at least a portion of the recovered portion of the oil-in-water emulsion treatment fluid into an oleaginous fluid and an aqueous fluid

20210307023, Sep 30, 2021

Jun 11, 2021

17/304008

- Suwon-si, KR
Aris Papasakellariou - Houston TX, US
Li Guo - Allen TX, US

H04W 72/10
H04W 4/40
H04W 72/04
H04B 7/26

A method of a first user equipment (UE) in a wireless communication system is provided. The method comprises: receiving, from a second UE via a sidelink, signals including information to select resources for at least one of aperiodic traffic or periodic traffic; decoding sidelink control information (SCI) from the information included in the signals; performing, over a sensing window, a signal measurement of the received signals; identifying a resource selection window based on a latency requirement; reserving the resources for the at least one of aperiodic traffic or periodic traffic in a frequency domain and a time domain based on the decoded SCI and a result of the signal measurement, the resources being identified within a resource selection window; and transmitting, to the second UE via the sidelink, the at least one of aperiodic traffic or periodic traffic using the reserved resources.