Li Guo

8617707, Dec 31, 2013

Mar 24, 2009

12/988992

Todd D. Krauss - Penfield NY, US
Christopher Evans - Rochester NY, US
Li Guo - Rockville MD, US
Jeffrey J. Peterson - Rochester NY, US

University of Rochester - Rochester NY

B32B 5/16

428402, 428403, 427212, 977773, 977774, 977775, 977814

Disclosed herein are magic size nanoclusters comprising lead and one or more chalcogens. The disclosed magic size nanoclusters have both spectrally narrow fluorescence and ultra-high quantum efficiencies. Further disclosed herein is a method for preparing PbS, PbSe, and PbTe magic size nanoclusters. The yield of magic size nanoclusters can be increased by using anion sources enriched for secondary phosphines. The use of enriched secondary phosphine anion sources also increases the yield of quantum nanostructures.

20160280632, Sep 29, 2016

Jun 6, 2016

15/174306

- Madison WI, US
Li Guo - Blue Bell PA, US
Michael Giuliano - Derby CT, US

WISCONSIN ALUMNI RESEARCH FOUNDATION - Madison WI

C07C 205/44
C07C 205/55
C07C 201/12

The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline derivative to provide cyclically constrained α-substituted-γ-nitro-aldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96 to >99% e.e.).The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to cyclically constrained protected γ-amino acid residues, which are essential for systematic conformational studies of γ-peptide foldamers. New methods are also provided to prepare other γ-amino acids and peptides. These new building blocks can be used to prepare foldamers, such as α/γ-peptide foldamers, that adopt specific helical conformations in solution and in the solid state.

20150148523, May 28, 2015

Jan 28, 2014

14/166007

- Madison WI, US
Li Guo - Blue Bell PA, US
Michael Giuliano - Derby CT, US

Wisconsin Alumni Research Foundation - Madison WI

C07K 7/06
C07C 271/66
C07C 205/55
C07C 269/00
C07K 5/065
C07K 5/107
C07C 201/12
C07C 205/44
C07C 271/24

530329, 568423, 560115, 562507, 560125, 530330

The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline derivative to provide cyclically constrained α-substituted-γ-nitro-aldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96 to >99% e.e.).The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to cyclically constrained protected γ-amino acid residues, which are essential for systematic conformational studies of γ-peptide foldamers. New methods are also provided to prepare other γ-amino acids and peptides. These new building blocks can be used to prepare foldamers, such as α/γ-peptide foldamers, that adopt specific helical conformations in solution and in the solid state.