US Patent:
20100098684, Apr 22, 2010
Inventors:
Gaetano J. Scuderi - Jupiter FL, US
Lewis S. Hanna - Naples FL, US
Robert Bowser - Cranberry Township PA, US
International Classification:
A61K 39/395
C07K 14/78
G01N 33/53
A61K 38/02
A61K 31/711
A61K 31/7105
A61P 19/02
A61P 37/06
US Classification:
4241301, 530395, 435 792, 514 2, 514 44 R, 514 44 A
Abstract:
Biomarkers, including isolated fibronectin-aggrecan complexes that correlate with spinal or joint pain and inflammation, and methods for their detection are provided. Also provided are methods for identifying treatment sites in the spine or joint for treatment of pain and inflammation by detecting the presence of, or increased levels of, fibronectin-aggrecan complexes. Methods for treating spinal or joint pain and inflammation are also provided.