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Laurie Beth Schenkel

from Belmont, MA
Age ~46
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Also known as:
Laurie B Schenkel, Laurie B Scheneke, Laurie L
Related to:
Mark A Schenkel, 41
Connected to:
Adam E Schenkelberg, 39Adina R Schenkenberger, 46Andrew J Schenkel, 43Ann J Schenke, 83Brian C Schenker, 53Carl R Schenker, 80Cory M Schenker, 35Craig I Schenker, 40Crystalyn R Schenkenberg, 45Dale W Schenkel, 64

Laurie Schenkel Phones & Addresses

  • Belmont, MA
  • Somerville, MA
  • 10 Bowdoin St, Boston, MA 02114 (857) 991-1644
  • 28 Exeter St, Boston, MA 02116
  • 3900 Harrison St, Oakland, CA 94611
  • Saint Louis, MO
  • Washington Crossing, PA
  • 10 Bowdoin St UNIT 508, Boston, MA 02114 (857) 991-1644

Publications

Us Patents

Benzothiazole Pi3 Kinase Modulators For Cancer Treatment

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US Patent:
7928140, Apr 19, 2011
Filed:
Aug 1, 2008
Appl. No.:
12/221416
Inventors:
Shon Booker - Thousand Oaks CA, US
Noel D'Angelo - Thousand Oaks CA, US
Derin C. D'Amico - Newbury Park CA, US
Longbin Liu - Thousand Oaks CA, US
Kristin Meagher - Thousand Oaks CA, US
Mark H. Norman - Thousand Oaks CA, US
Kathleen Panter - Cambridge MA, US
Laurie B. Schenkel - Boston MA, US
Adrian L. Smith - Simi Valley CA, US
Nuria A. Tamayo - Newbury Park CA, US
Douglas A. Whittington - Waltham MA, US
Ning Xi - Thousand Oaks CA, US
Kevin Yang - San Gabriel CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/38
US Classification:
514514, 544333, 544405, 5462811, 548143, 548161, 5483461
Abstract:
The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I.

Aurora Kinase Modulators And Method Of Use

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US Patent:
7981891, Jul 19, 2011
Filed:
Jun 30, 2010
Appl. No.:
12/828067
Inventors:
Holly Deak - Brookline MA, US
Stephanie Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Zihao Hua - Tewksbury CA, US
Mathew Martin - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip Olivieri - Charlestown MA, US
Kate Panter - Cambridge MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US
Ryan White - Somerville MA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/502
US Classification:
514248, 514311, 544237, 546152
Abstract:
The present invention relates to chemical compounds having a general formula I.

Aurora Kinase Modulators And Method Of Use

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US Patent:
8022221, Sep 20, 2011
Filed:
Feb 12, 2009
Appl. No.:
12/378426
Inventors:
Victor J. Cee - Thousand Oaks CA, US
Holly L. Deak - Brookline MA, US
Bingfan Du - Cambridge MA, US
Stephanie D. Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip R. Olivieri - Medford MA, US
Vinod F. Patel - Acton MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
C07D 401/14
C07D 403/14
A61K 31/53
A61K 31/4427
A61K 31/506
A61P 19/02
A61P 35/00
US Classification:
5462681, 546288, 514345, 514341, 514242, 514272, 514274, 514241, 514245, 51425201, 51425202, 5142521, 514256, 514269, 514275, 514277, 514336, 514340, 514348, 544182, 544320, 544322, 544408, 544180, 544209, 544219, 544238, 544239, 544240, 544295, 544297, 544310, 544317, 544324, 544328, 544331, 544405
Abstract:
The present invention relates to chemical compounds having a general formula I.

Inhibitors Of Pi3 Kinase

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US Patent:
8415376, Apr 9, 2013
Filed:
May 29, 2009
Appl. No.:
12/995431
Inventors:
Yunxin Y. Bo - Thousand Oaks CA, US
Shon Booker - Thousand Oaks CA, US
Marian Bryan - West Hills CA, US
Holly L. Deak - Brookline MA, US
Longbin Liu - Thousand Oaks CA, US
Kristin Andrews - Thousand Oaks CA, US
Nobuko Nishimura - West Hills CA, US
Mark H. Norman - Thousand Oaks CA, US
Kathleen Panter - Cambridge MA, US
Laurie Schenkel - Boston MA, US
Aaron C. Siegmund - Ventura CA, US
Nuria A. Tamayo - Newbury Park CA, US
Kevin Yang - San Gabriel CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/47
C07D 401/02
C07D 401/14
US Classification:
514314, 546167
Abstract:
The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X, X, Rand Z are as defined herein.

Aurora Kinase Modulators And Method Of Use

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US Patent:
8557816, Oct 15, 2013
Filed:
Jun 9, 2011
Appl. No.:
13/157195
Inventors:
Stephanie Geuns-Meyer - Medford MA, US
Victor J. Cee - Thousand Oaks CA, US
Isaac Marx - Somerville MA, US
Laurie Schenkel - Boston MA, US
Ryan White - Somerville MA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/502
US Classification:
514248, 514300, 544237, 546113
Abstract:
The present invention relates to chemical compounds having a general formula I.

Aurora Kinase Modulators And Method Of Use

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US Patent:
20070185111, Aug 9, 2007
Filed:
Jan 18, 2007
Appl. No.:
11/655642
Inventors:
Victor Cee - Thousand Oaks CA, US
Holly Deak - Brookline MA, US
Bingfan Du - Cambridge MA, US
Stephanie Geuns-Meyer - Medford MA, US
Brian Hodous - Cambridge MA, US
Hanh Nguyen - Arlington MA, US
Philip Olivieri - Medford MA, US
Vinod Patel - Acton MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US
International Classification:
A61K 31/53
A61K 31/503
C07D 403/14
US Classification:
514241000, 544209000, 514249000, 544237000
Abstract:
The present invention relates to chemical compounds having a general formula I wherein A, A, C, C, D, L, L, Z and R- are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

Aurora Kinase Modulators And Method Of Use

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US Patent:
20090069297, Mar 12, 2009
Filed:
Apr 3, 2008
Appl. No.:
12/080669
Inventors:
Victor Cee - Thousand Oaks CA, US
Holly Deak - Brookline MA, US
Bingfan Du - Cambridge MA, US
Stephanie Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Zihao Hua - Tewksbury CA, US
Mathew Martin - Cambridge MA, US
Isaac Marx - Somerville MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip Olivieri - Charlestown MA, US
Kathleen Panter - Cambridge MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US
Ryan White - Somerville MA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/502
C07D 237/30
A61K 31/55
A61P 35/00
C07D 403/14
US Classification:
51421705, 544237, 540599, 514248
Abstract:
The present invention relates to chemical compounds having a general formula Iwherein A, D′, L, L, R, Rand n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

Aurora Kinase Modulators And Method Of Use

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US Patent:
20110263530, Oct 27, 2011
Filed:
Jun 28, 2011
Appl. No.:
13/171355
Inventors:
Victor J. CEE - Thousand Oaks CA, US
Holly L. Deak - Brookline MA, US
Bingfan Du - Cambridge MA, US
Stephanie D. Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip R. Olivieri - Medford MA, US
Vinod F. Patel - Acton MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
A61K 31/69
A61K 31/50
C07D 401/12
A61K 31/502
A61K 31/444
C07F 5/04
C07D 401/14
A61K 31/501
C07F 9/6561
A61K 31/675
C07D 471/04
A61K 31/437
A61K 31/506
C07D 413/14
A61K 31/5377
A61P 35/00
A61P 35/02
C07D 237/20
US Classification:
514 64, 544224, 514247, 544237, 514248, 546261, 514335, 546 13, 51425202, 544232, 514 80, 546113, 514300, 544331, 514275, 544119, 5142345
Abstract:
The present invention relates to chemical compounds having a general formula Iwherein A, A, C, C, D, L, L, Z and R, R, R, Rand Rare defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
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Laurie Beth Schenkel from Belmont, MA, age ~46 Get Report