Inventors:
Mary K. Shriver - Bellevue WA
Larry H. Gosting - Snohomish WA
Edna S. Dickinson - Seattle WA
Janela McClure - City of Vashon Is. WA
Elaine K. Thomas - Seattle WA
Wesley L. Cosand - Bothell WA
Assignee:
Bristol-Myers Squibb Company - New York NY
International Classification:
G01N 33569
C12N 520
C07K 1528
A61K 3942
Abstract:
Methods and composition for HIV diagnosis and treatment using monoclonal antibodies reactive with one or more neutralizing regions of HIV proteins, using the peptides or homologs thereof from that region, and using related nucleic acid segments. Exemplary neutralizing regions include selected portions of the env and gag genes from various HIV isolates. Monoclonal antibody secreting cell lines include HIV-gp110-1, -2, -3, -4, -5 and -6 (A. T. C. C. Accession Nos. HB9175, HB9176, HB9177, HV9405, HB9406 and HB9404, respectively) and HIV-p25-2, -3, -6 and -7 (A. T. C. C. Accession Nos. HB9407, HB9408, HB9409 and HB9410, respectively).