Kyle E Hammerick

7557051, Jul 7, 2009

Mar 11, 2005

11/078907

WonHyoung Ryu - Stanford CA, US
Seoung Jai Bai - Stanford CA, US
Kyle Hammerick - Palo Alto CA, US
Robert Lane Smith - Palo Alto CA, US
Ralph S. Greco - Stanford CA, US
Friedrich B. Prinz - Woodside CA, US
Rainer J. Fasching - Mill Valley CA, US

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

H01L 21/00
B29C 45/00

438800, 26432816

Methods for compression molding through holes in polymer layers are provided, as are the resulting patterned polymer layers. Two key aspects of the invention are provision of a mold and substrate having different mechanical hardness, and provision of room for local flow of material. These aspects of the invention facilitate formation of through holes by compression molding that are not blocked or partially blocked by undesirable material. These polymer layers can be formed into three dimensional patterned structures by bonding patterned layers together. Since the layers include through holes, a three-dimensional polymer pattern can be formed. These patterned polymer layers and three dimensionally patterned polymer constructs have a wide variety of applications. For example, these constructs can be used for fabrication of micro-fluidic devices, and/or can be used for various medical and biological applications including drug delivery devices and tissue engineering devices.

20020173033, Nov 21, 2002

May 17, 2002

10/150399

Kyle Hammerick - Palo Alto CA, US
Friedrich Prinz - Woodside CA, US
Robert Smith - Palo Alto CA, US
Ralph Greco - Stanford CA, US
Rainer Fasching - Tiburon CA, US

C12M003/00

435/305200, 435/288500, 435/029000

A device, method and process for three-dimensional spatial localization and functional interconnection of the same or different types of cells. The two or three-dimensional device comprising multiple layers containing wells for cell deposition where both the wells and layers are interconnected through microfluidic channels. A process for fabricating the three-dimensional device and a method for depositing different types of cells within the device in a functional interdependent spatial orientation thereby mimicking physiological functions. The device is useful for diagnostic assays, determination of dysfunction of certain cells in the system, quantification of production of cellular proteins, metabolites, hormones or other cellular products, for organ or tissue replacement, for co-culturing different cells, for testing pharmaceutical agents and as a bioreactor for production of biologicals.

20060213259, Sep 28, 2006

Sep 22, 2005

11/233677

Friedrich Prinz - Woodside CA, US
Ye Tao - Stanford CA, US
Rainer Fasching - Mill Valley CA, US
Ralph Greco - Stanford CA, US
Kyle Hammerick - Palo Alto CA, US
Robert Smith - Palo Alto CA, US

B23Q 17/09
G01N 19/02

073104000

Sensors and systems for electrical, electrochemical, or topographical analysis, as well as methods of fabricating these sensors are provided. The sensors include a cantilever and one or more probes, each of which has an electrode at its tip. The tips of the probes are sharp, with a radius of curvature of less than about 50 nm. In addition, the probes have a high aspect ratio of more than about 19:1. The sensors are suitable for both Atomic Force Microscopy and Scanning Electrochemical Microscopy.

20170281833, Oct 5, 2017

Jun 15, 2017

15/624304

- Palo Alto CA, US
Kyle HAMMERICK - San Jose CA, US

BioInspire Technologies, Inc. - Palo Alto CA

A61L 31/04
A61L 31/06
A61K 31/56
A61M 31/00
A61L 31/14
A61L 31/16
A61K 9/00
A61L 31/02
A61L 31/08

Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.

20160158419, Jun 9, 2016

Feb 17, 2016

15/046285

- Palo Alto CA, US
Kyle HAMMERICK - San Jose CA, US

BIOINSPIRE TECHNOLOGIES, INC. - Palo Alto CA

A61L 31/04
A61L 31/16

Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.

20140255464, Sep 11, 2014

Mar 11, 2013

13/794355

Dorna HAKIMIMEHR - San Francisco CA, US
Kyle HAMMERICK - San Jose CA, US

BIOINSPIRE TECHNOLOGIES, INC. - Palo Alto CA

A61K 9/00

424443, 424400, 514 11, 514 44 R, 156 60, 1563066

Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.