US Patent:
20040010029, Jan 15, 2004
Inventors:
Gregory Merriman - Phillipsburg NJ, US
Philip Weintraub - Warren NJ, US
Jeffrey Sabol - Bridgewater NJ, US
Ramalinga Dharanipragada - Belle Mead NJ, US
Nicholas Hrib - Hillsborough NJ, US
John Jurcak - Bethlehem PA, US
Alexandre Gross - Jersey City NJ, US
Brian Whiteley - Lebanon NJ, US
Kwon Musick - Raritan NJ, US
Joseph Klein - Neshanic Station NJ, US
International Classification:
C07D333/72
C07D209/42
A61K031/405
A61K031/381
US Classification:
514/419000, 514/443000, 548/492000, 549/055000
Abstract:
This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.