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Kurt R Brunden

from Media, PA
Age ~67
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Also known as:
Kurt R Runden, Curt Brunden, Kurt Brunoe, Kurt N
Phone and address:
308 Woodland Ave, Media, PA 19063
Related to:
Sherry Beecher, 68
Connected to:
William J Brundick, 97Alisha L Brundige, 38Bennie L Brundidge, 35Bernard Brundidge, 63Cedric J Brundidge, 67Charlotte Brundies, 35Connie L Brundige, 68Dakota Brundige, 31Daniel L Brundige, 58Eric Brundidge, 40

Kurt Brunden Phones & Addresses

  • 308 Woodland Ave, Media, PA 19063
  • 664 Glen Eden Ct, Aurora, OH 44202
  • Brandon, MS
  • Rochester, MN
  • Jackson, MS

Resumes

Resumes

Kurt Brunden Photo 1

Director, Cndr Drug Discovery And Professor, Research Faculty

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Location:
Media, PA
Industry:
Pharmaceuticals
Work:
University of Pennsylvania - University of Pennsylvania since Sep 2007
Director, CNDR Drug Discovery and Professor, Research Faculty
Athersys 2000 - 2007
SVP, Biopharma
Gliatech Inc. 1991 - 2000
VP, Research
Education:
Purdue University 1980 - 1985
Ph.D., Biochemistry Western Michigan University 1976 - 1980
B.S., Biology/Chemistry
Skills:
Drug Discovery
Biopharmaceuticals
Molecular Biology
Lifesciences
Biotechnology
Biochemistry
Neuroscience
Cell Culture
Western Blotting
Protein Chemistry
In Vivo
Cell Biology
Life Sciences
Drug Development
Cell
Assay Development
Immunology
Research
Kurt Brunden Photo 2

Kurt Brunden

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Publications

Us Patents

Human Glycine Transporter Type 2

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US Patent:
6416975, Jul 9, 2002
Filed:
Nov 12, 1998
Appl. No.:
09/191468
Inventors:
Michael J. Gallagher - Shaker Heights OH
Loyd H. Burgess - Solon OH
Kurt R. Brunden - Aurora OH
Assignee:
Gliatech, Inc. - Cleveland OH
International Classification:
C12D 2106
US Classification:
435 691, 4352523, 435320, 435325, 536 235
Abstract:
Nucleic acids and proteins derived from sequences of the human glycine transporter type 2 are described.

Nitrogen-Containing Compounds And Their Use As Glycine Transport Inhibitors

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US Patent:
6946474, Sep 20, 2005
Filed:
Sep 13, 2001
Appl. No.:
10/344962
Inventors:
Syed M. Ali - Solon OH, US
Kurt R. Brunden - Aurora OH, US
Jack B. Jiang - Orange Village OH, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D211/72
C07D211/84
C07D213/72
C07D231/75
C07D231/38
US Classification:
514313, 514353, 514381, 514404, 514535, 514542, 514550, 514562, 514586, 546160, 546305, 548251, 5483684, 5483691, 560 16, 560125, 560426, 562427, 562432, 564 27
Abstract:
The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such compounds for inhibiting glycine transporters and methods for using such compounds for the treatment of disease states in which glycine is involved.

Substituted Hydrazine Derivatives

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US Patent:
7049343, May 23, 2006
Filed:
Sep 7, 2001
Appl. No.:
10/344966
Inventors:
Syed M. Ali - Solon OH, US
Kurt R. Brunden - Aurora OH, US
Dario Doller - Branford CT, US
Brian Herbert - Streetsboro OH, US
Jack B. Jiang - Orange Village OH, US
Amy Jordan - Parma OH, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A01N 74/34
A61K 31/175
US Classification:
514583, 564148, 564310
Abstract:
A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.

Cycloalkyl-Dione Derivatives And Methods Of Their Use

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US Patent:
8530520, Sep 10, 2013
Filed:
Jun 6, 2012
Appl. No.:
13/489745
Inventors:
Onur Atasoylu - Izmir, TR
Carlo Ballatore - Philadelphia PA, US
Kurt R. Brunden - Media PA, US
Longchuan Huang - Philadelphia PA, US
Donna M. Huryn - Allentown NJ, US
Michael James - Philadelphia PA, US
Francesco Piscitelli - Strongoli Marina, IT
James Soper - Cambridge MA, US
John Q. Trojanowski - Philadelphia PA, US
Assignee:
The Trustees Of The University Of Pennsylvania - Philadelphia PA
International Classification:
A61K 31/18
US Classification:
514604
Abstract:
The present invention is directed to carboxylic acid-containing pharmaceutical compounds where the carboxylic acid moieties have been substituted with cycloalkyl-dione derivatives, as well as tautomers and pharmaceutically acceptable salt forms thereof. These bioisosteric replacements improve the compound's ability to effectively cross the blood brain barrier and result in improved pharmacokinetic, toxicological, and/or safety profiles.

Process For Inhibiting Complement Activation Via The Alternative Pathway

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US Patent:
20020015701, Feb 7, 2002
Filed:
Oct 12, 2001
Appl. No.:
09/976649
Inventors:
Kurt Brunden - Aurora OH, US
James Parent - Cleveland OH, US
International Classification:
A61K039/395
US Classification:
424/139100
Abstract:
A process of inhibiting activation of complement via the alternative pathway, including inhibiting the formation of complement activation products via the alternative pathway, is provided.

Nitrogen-Containing Compounds And Their Use As Glycine Transport Inhibitors

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US Patent:
20020082283, Jun 27, 2002
Filed:
Sep 13, 2001
Appl. No.:
09/951170
Inventors:
Syed Ali - Solon OH, US
Kurt Brunden - Aurora OH, US
Jack Jiang - Orange Village OH, US
Assignee:
Gliatech, Inc.
International Classification:
A61K031/47
A61K031/428
A61K031/415
A61K031/41
A61K031/166
US Classification:
514/367000, 514/313000, 514/381000, 514/407000, 514/618000, 546/159000, 548/161000, 548/251000, 548/367400, 564/162000
Abstract:
A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.

Substituted Hydrazine Derivatives

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US Patent:
20020120149, Aug 29, 2002
Filed:
Sep 7, 2001
Appl. No.:
09/948848
Inventors:
Syed Ali - Solon OH, US
Kurt Brunden - Aurora OH, US
Dario Doller - Branford CT, US
Brian Herbert - Streetsboro OH, US
Jack Jiang - Orange Village OH, US
Amy Jordan - Parma OH, US
International Classification:
C07D213/88
C07D207/34
C07C311/44
C07C243/22
US Classification:
546/306000, 548/557000, 558/408000, 560/019000, 564/081000, 564/148000, 564/253000, 564/311000
Abstract:
A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.

Use Of Histamine H3 Receptor Inverse Agonists For The Control Of Appetite And Treatment Of Obesity

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US Patent:
20030069295, Apr 10, 2003
Filed:
Aug 15, 2001
Appl. No.:
09/930356
Inventors:
Stephen Yates - Aurora OH, US
Clark Tedford - South Russell OH, US
Kurt Brunden - Aurora OH, US
Assignee:
Gliatech, Inc.
International Classification:
A61K031/4164
US Classification:
514/396000
Abstract:
A method for the use of histamine Hreceptor inverse agonists in the regulation of appetite and treatment of obesity is disclosed. Presently preferred inverse agonists are imidazole derivatives.
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Kurt R Brunden from Media, PA, age ~67 Get Report