Kristin Weidemaier

7496392, Feb 24, 2009

Nov 26, 2003

10/721797

Javier Alarcón - Durham NC, US
Kristin Weidemaier - Raleigh NC, US
Terry J. Amiss - Cary NC, US
John D. DeNuzzio - Chapel Hill NC, US
Christopher C. Herdman - Durham NC, US
Ross Wayne Jacobson - Hillsborough NC, US
J. Bruce Pitner - Durham NC, US
Douglas B. Sherman - Durham NC, US

Becton, Dickinson and Company - Franklin Lakes NJ

A61B 5/145

600317, 600310

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is described. An optical conduit, preferably an optical fiber, has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and may include at least one binding protein adapted to bind with at least one target analyte. The sensing element further may also include at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.

7787923, Aug 31, 2010

Oct 19, 2004

10/967220

Javier Alarcon - Durham NC, US
Kristin Weidemaier - Raleigh NC, US
Terry J. Amis - Cary NC, US
John D. DeNuzzio - Monkton MD, US
Christopher C. Herdman - Chappaqua NY, US
Ross W. Jacobson - Hillsborough NC, US
J. Bruce Pitner - Durham NC, US
Douglas B. Sherman - Durham NC, US
Steven Keith - Chapel Hill NC, US

Becton, Dickinson and Company - Franklin Lakes NJ

A61B 5/145

600316, 600317, 600342

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.

7792561, Sep 7, 2010

Aug 16, 2007

11/840069

Javier Alarcon - Durham NC, US
Kristin Weidemaier - Raleigh NC, US
Terry J. Amiss - Cary NC, US
John D. Denuzzio - Chapel Hill NC, US
Christopher C. Herdman - Durham NC, US
Ross Wayne Jacobson - Hillsborough NC, US
J. Bruce Pitner - Durham NC, US
Douglas B. Sherman - Durham NC, US

Becton, Dickinson and Company - Franklin Lakes NJ

A61B 5/145

600317, 600310

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.

20020148288, Oct 17, 2002

Jan 10, 2002

10/043762

Patrick Clark - Valley Forge PA, US
Kristin Weidemaier - Yardley PA, US

G01N017/00
G01B021/08

073/15000R

A method for predicting the outdoor durability of a first coating relative to the outdoor durability of at least one other of a set of coatings, all of the coatings having been formed from aqueous coating compositions comprising a thermoplastic emulsion polymer, particularly a predominantly acrylic thermoplastic emulsion polymer, and, optionally, a pigment, comprising exposing the set of coatings to the same ambient outdoor conditions for the same period of time, subjecting the exposed coatings to a chemiluminescence test, and comparing the result of said chemiluminescence test performed on the first coating to the corresponding result for at least one other of the set of coatings.

20030198125, Oct 23, 2003

Apr 15, 2003

10/414357

Michael Linsen - North Wales PA, US
Mark Schure - Blue Bell PA, US
Kristin Weidemaier - Raleigh NC, US

B01F015/04

366/152100, 366/160200

An automated fluid formulating system for use in small scale laboratory operations. The system utilizes a computer to provide precise control over the measurement of ingredients and the entire formulating process. The novel feature of this invention is that it can provide precise control over the formulating of high viscosity, high solid fluids, such as emulsions and gels. Further, a pre-programmed cleaning cycle can be input into the computer to automatically clean the mixing elements so that the mixing elements do not contaminate subsequent formulations with materials from the prior formulation.

20070111196, May 17, 2007

Aug 21, 2006

11/465857

Javier Alarcon - Durham NC, US
Kristin Weidemaier - Raleigh NC, US
David Kurisko - Raleigh NC, US
Srinivasan Sridharan - Bel Air MD, US

C12Q 1/00

435004000

The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor.

20090258373, Oct 15, 2009

Apr 13, 2009

12/422381

Kristin Weidemaier - Raleigh NC, US
W. Shannon Dillmore - Raleigh NC, US

BECTON, DICKINSON AND COMPANY - Franklin Lakes NJ

G01N 33/53
G01N 33/566

435 71, 436501

A method is disclosed for accurately determining the concentration of a target analyte utilizes reagent pairs having different affinity for the target. The different affinity provides distinct binding profiles that can be analyzed to absolutely determine the analyte concentration. The method provides an assay system having expanded dynamic range to cover a wider range of analyte concentration and can overcome the hook-effect that commonly exists in homogenous assay systems. The method utilizes distinguishable signals that allows for the analysis of multiple binding profiles and multiplex analysis.

20090305231, Dec 10, 2009

Apr 8, 2009

12/420574

Kristin Weidemaier - Raleigh NC, US
Melody Kuroda - Durham NC, US
Lori Pederson Allphin - Wake Forest NC, US
Christian Sandmann - Raleigh NC, US
Adam C. Curry - Raleigh NC, US
Robert A. Fulcher - Hillsborough NC, US

G01N 33/53
C12M 1/34
C12Q 1/70
C12Q 1/68

435 5, 4352872, 4352887, 435 6, 435 71, 977920

Coated nanoparticles comprising a core surrounded by a shell that increases the reflectance of the nanoparticle, wherein the coated nanoparticle does not include a Raman-active molecule, are provided. Test devices and immunoassay methods utilizing the coated nanoparticles are provided.