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Krista Dubin Phones & Addresses
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444 57Th St, New York, NY 10022 (212) 355-5973
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444 E 57Th St APT 6D, New York, NY 10022 (212) 355-5973
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1008 Springs Fireplace Rd, East Hampton, NY 11937 (631) 537-7315
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Cambridge, MA
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1008 Springs Fireplace Rd, East Hampton, NY 11937 (212) 355-5973
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Us Patents
Methods And Compositions For Identifying And Treating Subjects At Risk For Checkpoint Blockade Therapy Associated Colitis
View pageUS Patent:
20180360892, Dec 20, 2018
Filed:
May 21, 2018
Appl. No.:
15/984613
Inventors:
- New York NY, US
Jedd D. Wolchok - New York NY, US
Krista Dubin - New York NY, US
Jedd D. Wolchok - New York NY, US
Krista Dubin - New York NY, US
International Classification:
A61K 35/742
A61K 9/00
G01N 33/569
A61K 45/06
A61K 9/00
G01N 33/569
A61K 45/06
Abstract:
The present invention relates to methods and compositions for identifying subjects treated with or considered for treatment with checkpoint blockade therapeutic agents that are at higher or lower risk for developing checkpoint therapy associated colitis, by analyzing the intestinal microbiome of those subjects. It is based, at least in part, on the discovery that the abundance of certain intestinal microbiota of the phyla Bacteroidetes, including the bacteria in the families Bacteroidaceae, Rikenellaceae, and Barnesisllaceae, and/or an increase or decrease in microbial genetic pathways involved in polyamine transport and/or B vitamin biosynthesis (e.g., (riboflavin (B2), pantothenate (B5) and thiamine (B1)) are associated with the likelihood of developing checkpoint therapy associated colitis.