Koon Pak Phones & Addresses
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Cypress, CA
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7860 Valley View St, Buena Park, CA 90620 (714) 670-8598
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La Palma, CA
Publications
Us Patents
Molecular Probes For Multimodality Imaging Of Anionic Membrane Surfaces
View pageUS Patent:
20130323172, Dec 5, 2013
Filed:
Jun 4, 2013
Appl. No.:
13/909684
Inventors:
Kai Chen - San Gabriel CA, US
Koon Y. Pak - Malvern PA, US
Koon Y. Pak - Malvern PA, US
International Classification:
A61K 51/04
G01N 33/50
A61B 6/03
A61K 51/08
A61M 5/00
A61B 5/00
G01N 33/50
A61B 6/03
A61K 51/08
A61M 5/00
A61B 5/00
US Classification:
424 189, 600431, 600427, 546 12, 530330, 435 29
Abstract:
Embodiments provide dual modality probes for imaging phosphatidylserine (PS) exposure and other anionic membrane surfaces. In various embodiments, the probes were constructed by utilizing a) the high selectivity of synthetic zinc (II) dipicolylamine coordination complexes (Zn-DPA) for targeting externalized PS which over-expresses in apoptotic and necrotic cells, b) a near-infrared (NIR) dye for optical imaging, and c) a widely used clinically approved radionuclide for PET (or SPECT) imaging. A variety of linking elements were incorporated into the probes between the Zn-DPA and radionuclide motif to modulate the pharmacokinetics. The in vitro and in vivo data of radiolabeled dipicolylamine probes demonstrated their utilities for imaging PS exposure with multiple imaging modalities.