Inventors:
Hiroshi Yamaguchi - Bronx NY
Koichi Furukawa - New York NY
Philip O. Livingston - New York NY
Kenneth O. Lloyd - Bronx NY
Herbert F. Oettgen - New Canon CT
Lloyd J. Old - New York NY
Sheila R. Fortunato - Hollis NY
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:
C12N 512
C07K 1528
A61K 3900
G01N 3353
Abstract:
This invention provides a monoclonal antibody, produced by the hybridoma cell line designated GXM1, which specifically binds to a human class 1tumor antigen. This invention also provides a human monoclonal antibody, produced by a hybridoma cell line designated HJM1, which specifically binds to each of the ganglioside antigens GD2, GD3, GM3 and GD1b. This invention further provides a human monoclonal antibody, produced by a hybridoma cell line designated FCM1, which specifically binds to the ganglioside antigens GM3 and GD1a. Finally, this invention provides a human monoclonal antibody, produced by a hybridoma cell line designated DSM1, which specifically binds to a human class 2 tumor protein antigen.