Inventors:
Gary Arthur Amstutz - San Jose CA
Stephen Scott Bowersox - Menlo Park CA
Kishorchandra Gohil - Richmond CA
Peter Isadore Adriaenssens - Mountain View CA
Ramasharma Kristipati - Fremont CA
Assignee:
Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:
A61K 3800
A61K 3802
C07K 500
C07K 700
Abstract:
A method of preventing progression of neuropathic pain is disclosed. The method includes administering to a subject an N-type voltage-sensitive calcium channel blocking compound which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are formulations effective to stabilize omega conotoxin peptide preparations at elevated temperatures. Novel omega conopeptides also form part of the invention.