Inventors:
Jon A. Weidanz - Miami FL, US
Kimberlyn F. Card - Pembroke Pines FL, US
Linda A. Sherman - La Jolla CA, US
Norman R. Klinman - La Jolla CA, US
Hing C. Wong - Weston FL, US
Assignee:
Altor BioScience Corporation - Miramar FL
International Classification:
C12N 5/00
C12N 1/06
US Classification:
435375, 514 2, 530300, 530350, 5303871, 5303877, 5303887, 53038875, 5303888, 5303917, 4241301, 4241331, 4241351, 4241531, 4241541, 4241731
Abstract:
The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-chain antibody (sc-Ab). Further disclosed are methods and compositions for testing and using the molecules.