Inventors:
H. William Bosch - Bryn Mawr PA, US
Greta G. Cary - Landsdale PA, US
Douglas C. Hovey - Gilbertsville PA, US
Rajeev A. Jain - Framingham MA, US
Laura J. Kline - Harleysville PA, US
Kevin D. Ostrander - Ringoes NJ, US
Niels P. Ryde - Malvern PA, US
Stephen B. Ruddy - Schwenksville PA, US
Assignee:
Elan Pharma International Ltd. - Athlone, County Westmeath
International Classification:
A61K 9/14
A61K 9/00
A61K 31/66
A61K 31/385
A61K 31/522
A61K 31/525
A61K 31/557
A61K 36/82
A61K 36/328
A61K 36/886
A61K 38/17
A61K 48/00
US Classification:
424489, 424729, 424744, 424748, 424768, 424776, 514 121, 514102, 514251, 51426331, 514440, 514561, 514573
Abstract:
Nanoparticulate compositions comprising at least one poorly soluble MAP kinase inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.