Kenneth Alan Messier

20020187182, Dec 12, 2002

Feb 14, 2002

10/075355

Hildegard Kramer - Westport CT, US
Luis Avila - Arlington MA, US
C. Philbrook - Boston MA, US
Peter Jarrett - Sudbury MA, US
Barbara Huibregtse - Shrewsbury MA, US
Liesbeth Brown - West Newton MA, US
Kenneth Messier - Griswold CT, US
Michael Bassett - Providence RI, US
Edward Doherty - Mansfield MA, US
John Traverse - Somerville MA, US

Genzyme Corporation

A61K009/70
B29C043/10

424/443000, 424/423000, 264/571000

A porous, water-absorbing fleece is made from crosslinkable biocompatible and biodegradable macromers. A solution of the macromers is frozen and vacuum-dried through lyophilization. The “fleece” formed by lyophilization is then crosslinked, for example by heat and/or an initiator of crosslinking. The resulting crosslinked material is highly water absorbent, readily swelling to at least its size before lyophilization, but retains macroporosity as well as the microporosity of a gel. Porosity and strength of the fleece can be controlled by initial polymer concentration and extent of crosslinking. The fleece materials can be used in different embodiments for applications in medicine and tissue engineering.

20050281866, Dec 22, 2005

May 23, 2005

11/136328

Peter Jarrett - Sudbury MA, US
Kenneth Messier - Griswold CT, US
Robert Miller - E. Bridgewater MA, US
C. Philbrook - Boston MA, US
Hildegard Kramer - Westport CT, US
J. Kablik - Tyngsboro MA, US
Erika Johnston - Waltham MA, US
Luis Avila - Arlington MA, US
Arthur Coury - Boston MA, US

Genzyme Corporation - Cambridge MA

A61L015/16

424448000

Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.

46242562, Nov 25, 1986

Sep 11, 1985

6/774636

Kenneth A. Messier - Jewett City CT
Joseph D. Rhum - Old Lyme CT

Pfizer Hospital Products Group, Inc. - New York NY

A61L 1700

1283355

High molecular weight caprolactone polymers are coated on surgical sutures to improve suture properties such as smooth surface, single knot slipdown, two throw knot slipdown for repositioning, and three throw knot security.

56817401, Oct 28, 1997

Jun 5, 1995

8/463658

Kenneth A. Messier - Cranston RI
Nicholas F. Warner - Belmont MA

CytoTherapeutics, Inc. - Providence RI

C12M 124
A01N 102

4352841

Bioartificial organ storage and transport apparatus having a media storage container. The apparatus is designed to securely maintain a bioartificial organ within the container in a sealed environment. The apparatus may also allow for gas exchange and media exchange to ensure the viability of the bioartificial organ. In addition, the apparatus may use a secondary container and cap, designed to allow access to the media storage container and allow for gas exchange and media exchange.