Kenn Richard Oldham

20120270256, Oct 25, 2012

Jan 23, 2012

13/356286

Kenn Oldham - Ann Arbor MI, US
Thomas D. Wang - Ann Arbor MI, US
Zhongyao Liu - Ann Arbor MI, US
Jing Yong Ye - San Antonio TX, US

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

F21V 14/06
G01N 21/64

435 29, 362319

An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.

20110125029, May 26, 2011

Oct 29, 2010

12/916159

Thomas D. Wang - Ann Arbor MI, US
Katsuo Kurabayashi - Ann Arbor MI, US
Kenn Oldham - Ann Arbor MI, US
Zhen Qiu - Ann Arbor MI, US

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

A61B 6/00

600476

An optical device is described that may be used as a microscope system for real-time, three-dimensional optical imaging. The device includes a miniature, fiber optic, intra-vital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer.

20220409790, Dec 29, 2022

Jun 29, 2021

17/362699

- Ann Arbor MI, US
Kaylee J. Smith - Ann Arbor MI, US
Kenn Oldham - Ann Arbor MI, US
Jason Smyth - Ann Arbor MI, US

A61M 1/16
A61M 1/26
B01L 3/00

A peristaltic pump-based apparatus for capturing circulating tumor cells (CTCs) from blood is provided that includes a feedback control architecture that uses models of pump operation and measures of internal pressure fluctuations of the pump (e.g., in the form time-varying and/or position-dependent pressure oscillation data) to adjust pump operating characteristics that smooth pump operation, thereby improving viscosity and consistency of fluid flowing through the pump to a connected microfluidic capture device.

20200260975, Aug 20, 2020

Feb 18, 2020

16/793650

- Ann Arbor MI, US
Kenn Oldham - Ann Arbor MI, US
Lu Wang - Ann Arbor MI, US
Sardar Ansari - Richmond VA, US

A61B 5/03
A61B 5/00
A61B 5/0215

Devices and techniques for continuously monitoring pressure and simultaneously monitoring changes in blood flow, vascular resistance, and/or vascular behavior are provided. The techniques are employed in measuring intracranial pressure (ICP), while simultaneously measuring cerebral blood flow and/or cerebrovascular resistance or behavior. A sensor device includes an optical and piezoelectric sensing assembly integrated into a deployable ICP monitoring device.

20200054221, Feb 20, 2020

Oct 25, 2017

16/344671

- Ann Arbor MI, US
Sardar Ansari - Richmond VA, US
Lu Wang - Ann Arbor MI, US
Kayvan Najarian - Northville MI, US
Kenn Oldham - Ann Arbor MI, US

A61B 5/0295
A61B 5/0225
A61B 5/02
A61B 5/1455

A wearable assembly has a pulse plethysmography (PPG) sensor and a piezoelectric pressure sensor and is attachable to a patient's finger or other area corresponding to a peripheralvascular region, and further includes a signal processor configured to monitor blood flow dependent measurements and pressure measurements over time, comparing these measurements to determine properties of the vascular region, such as vascular resistance of a blood vessel, vascular radius of the blood vessel, vascular stiffness of the vascular region, blood pressure, and/or cardiac vascular power. The signal processor may apply a hysteresis comparison of the sensor outputs, e.g., using an elliptical model, and in some examples may apply an extended Kalman filter for optimizing output of the vascular region properties.

20150305632, Oct 29, 2015

Mar 31, 2015

14/675062

- Ann Arbor MI, US
Kenn Oldham - Ann Arbor MI, US
Daniel Slavin - Ann Arbor MI, US
Ashwin Belle - Ann Arbor MI, US
Kevin R. Ward - Superior Township MI, US
Sardar Ansari - Richmond VA, US
Rodney C. Daniels - Ann Arbor MI, US

A61B 5/0295
A61M 5/172
A61B 5/021
A61B 5/02
A61B 5/0205
A61B 5/024

The invention is a passive, wearable sensor that uses a thin piezoelectric material to produce a time history of blood pressure of the patient, with signal processing algorithms to extract physiological information. The sensor consists of a piezoelectric transducer set in a polymer laminate that can be applied to the finger or wrist of the patient. During use, a combination of compressive and bending deformation in the piezoelectric layer in response to blood pressure in the finger or wrist as a voltage output. Using signal processing techniques, the raw signal is filtered and decomposed to obtain a information to form derivative signals such as blood pressure, pulse pressure, pulse pressure variability, heart rate, heart rate variability, and respiratory rate which can be very important pre-cursors in the monitoring of the patient's physiological conditions.