US Patent:
20100209467, Aug 19, 2010
Inventors:
William D. Carlson - Weston MA, US
Peter C. Keck - Millbury MA, US
Michael Sworin - Marlborough MA, US
Kellie Watson - Sudbury MA, US
Philippe Bey - Boston MA, US
Romesh Subramanian - Quincy MA, US
Assignee:
Thrasos Therapeutics , Inc. - Hopkinton MA
International Classification:
A61K 9/00
C07K 16/00
A61K 39/395
C07K 5/10
C07K 7/06
C07K 7/08
C07K 14/00
A61K 38/07
A61K 38/08
A61K 38/10
A61K 38/16
C07K 7/64
A61K 38/12
A61P 1/16
A61P 35/00
A61P 29/00
A61P 25/00
A61P 19/10
A61P 19/02
A61P 9/00
A61K 39/00
G01N 33/53
G06G 7/48
A01K 67/027
C12N 5/10
B05D 1/00
US Classification:
424422, 5303879, 5303873, 4241391, 530330, 530329, 530328, 530327, 530326, 530324, 514 17, 514 16, 514 15, 514 14, 514 13, 514 12, 530317, 514 11, 4241841, 435 71, 703 11, 436501, 800 13, 435325, 427 224
Abstract:
The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.