Inventors:
- New York NY, US
Helen H. LU - New York NY, US
Sarah E. DE LEO - Baton Rouge LA, US
Keenan T. BASHOUR - Hillsborough CA, US
Danielle BOGDANOWICZ - Cortlandt Manor NY, US
Philip CHUANG - New York NY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
C12N 5/00
D04B 21/12
C12N 5/0775
D06M 15/15
C12N 5/0783
A61K 35/17
Abstract:
The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, T cell or stem cell expansion. In another aspect, the disclosure provides for an electrospun mesh substrate and methods of using thereof comprising a silicone rubber composition, for example, polydimethylsiloxane, PLC, or combinations thereof.