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Katrin Tiemann

from Arcadia, CA
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Connected to:
Blake E Tiemann, 53Crystal L Tiemann, 34Elaine R Tiemann, 63Justin C Tiemann, 41Stacey A Tiemann, 47Mary A Tiemeier, 73Nancy S Tiemeier, 62Susan R Tiemens, 56Frances Tiemersma, 123Cindy A Tiemeyer, 64

Katrin Tiemann Phones & Addresses

  • Arcadia, CA
  • Pasadena, CA
  • 204 S Holliston Ave APT 12, Pasadena, CA 91106

Work

Company: City of hope Jul 2008 Position: Research fellow

Education

Degree: Diplom School / High School: Julius-Maximilians-Universität Würzburg 1996 to 2003 Specialities: Biology (Microbiology, Human Genetics, Biochemistry)

Skills

Cloning • Molecular Biology • flow cytometry • real-time PCR • cell culture • siRNA • protein expression/detection and cancer ...

Industries

Research

Resumes

Resumes

Katrin Tiemann Photo 1

Katrin Tiemann

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Position:
Research Fellow at City of Hope
Location:
Greater Los Angeles Area
Industry:
Research
Work:
City of Hope since Jul 2008
Research Fellow
University of York 2003 - 2007
PhD
Education:
Julius-Maximilians-Universität Würzburg 1996 - 2003
Diplom, Biology (Microbiology, Human Genetics, Biochemistry) University of Leeds 2000 - 2001
Erasmus, Adenoviruses and cancerAdenovirus 12 (Ad12) can cause cancer in rodents while Ad 5 does not. The comparison of Ad5 and Ad12 yielded a difference in an alanine rich region found in the E1A gene. My project was about trying to delete the Alanine region and to investigate whether this region was responsible or played a role in the cancer development of Ad12.
Skills:
Cloning
Molecular Biology
flow cytometry
real-time PCR
cell culture
siRNA
protein expression/detection and cancer biology

Publications

Us Patents

Rna Aptamers Against Baff-R As Cell-Type Specific Delivery Agents And Methods For Their Use

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US Patent:
20160076036, Mar 17, 2016
Filed:
Apr 13, 2015
Appl. No.:
14/685486
Inventors:
- Duarte CA, US
Katrin TIEMANN - Pasadena CA, US
Jiehua ZHOU - Monrovia CA, US
Britta VALLAZZA - Hagen, DE
International Classification:
C12N 15/113
A61K 47/48
A61K 31/713
C12N 15/115
Abstract:
In one embodiment, a B cell specific aptamer-siRNA chimera is provided. The B cell specific aptamer-siRNA chimera may include an RNA aptamer that binds BAFF-R and an siRNA molecule conjugated to the RNA aptamer via a nucleotide linker. In another embodiment, a B cell specific RNA aptamer is provided. The RNA aptamer may be a molecule that binds to BAFF-R that has the sequence SEQ ID NO:37, SEQ ID NO:38 or SEQ ID NO:39. In some embodiments, the RNA aptamer is conjugated, via a nucleotide linker, to an siRNA molecule that suppresses expression of one or more target oncogenes in one or more B cells. In one aspect, the one or more target oncogenes are selected from Bcl6, Bcl2, STAT3, Cyclin D1, Cyclin E2 and c-myc. In another embodiment, methods for treating a B cell malignancy in a cancer patient are provided. Such methods may include administering a therapeutically effective amount of a therapeutic composition, the therapeutic composition comprising a B cell specific RNA aptamer that binds BAFF-R.
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Katrin Tiemann from Arcadia, CA Get Report