Inventors:
- North Chicago IL, US
Lihua YANG - Westborough MA, US
Matthew HERIGSTAD - Charlestown MA, US
Hong YANG - Worcester MA, US
Kartik SUBRAMANIAN - Northborough MA, US
Xiaobei ZENG - Carolina PR, US
Diane D. DONG - Shrewsbury MA, US
Wen Chung LIM - Worcester MA, US
Kathreen A. GIFFORD - Marlborough MA, US
Zehra KAYMAKCALAN - Westborough MA, US
Christopher CHUMSAE - North Andover MA, US
Assignee:
AbbVie, Inc. - North Chicago IL
International Classification:
C07K 16/24
A61K 47/18
A61K 47/26
A61K 39/395
Abstract:
The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.