Inventors:
William H. Bunnelle - Mundelein IL, US
Jianguo Ji - Libertyville IL, US
Tao Li - Grayslake IL, US
Jennifer M. Pace - Grayslake IL, US
Karin R. Tietje - Mundelein IL, US
Kathleen H. Mortell - Chicago IL, US
Diana L. Nersesian - Gurnee IL, US
Michael R. Schrimpf - Grayslake IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 31/501
A61K 31/5025
A61K 31/4427
A61K 31/42
A61K 31/4436
C07D 401/04
C07D 403/04
C07D 405/04
C07D 409/04
C07D 471/04
C07D 491/04
C07D 498/04
C07D 513/04
C07D 515/04
A61P 29/00
C07D 231/12
C07D 417/04
C07D 285/08
C07D 285/12
C07D 239/42
C07D 263/34
C07D 413/02
C07D 413/14
C07D 271/107
C07D 487/04
C07D 215/12
C07D 261/12
C07D 401/14
C07D 413/04
C07D 23/56
A61K 31/41
A61K 31/425
A61K 31/426
A61K 31/427
A61K 31/4245
A61K 31/441
A61K 31/422
A61K 31/4155
US Classification:
51425206, 544238, 544333, 546113, 546256, 5462764, 546176, 5462767, 5462774, 51425202, 51425205, 51425204, 514256, 514406, 514372, 514363, 514361, 514374, 514364, 514339, 514357, 514378, 514338, 5483751, 548181, 548128, 548136, 548235, 548143, 548247, 5483625
Abstract:
Compounds of formula (I)Z-Ar—Ar (I)wherein Z is a diazabicyclic amine, Aris a 5- or 6-membered aromatic ring, and Aris selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.