US Patent:
20080227655, Sep 18, 2008
Inventors:
Michael Bevilacqua - Boulder CO, US
Victor Tryon - Woodinville WA, US
John Cheronis - Conifer CO, US
Kathleen Storm - Longmont CO, US
Karl Wassmann - Dover MA, US
International Classification:
C40B 30/06
C40B 40/08
Abstract:
Rodent gene expression data, in particular, gene expression profiles, are created and used to predict the efficacy of therapeutic agents on human biological conditions. Gene Profile data sets are derived from rodent subject samples and include quantitative, substantially repeatable measures of a distinct amount of RNA or protein constituent(s) in a signature panel selected such that measurement of the constituent(s) enables measurement of a biological condition of interest in both human and rodent subjects. Such profile data sets may be used to predict the therapeutic efficacy of a therapeutic agent in humans.