Inventors:
John Swart - Orange City IA, US
Eric Vaughn - Ames IA, US
Karen Freking - Hospers IA, US
Michael Roof - Ames IA, US
Phillip Hayes - Maurice IA, US
Reid Phillips - Parkville MO, US
International Classification:
A61K 39/116
Abstract:
The present invention provides a composition and an improved single dose vaccine against and an improved single dose vaccine against and which provides one or more of the following: 1) confers effective immunity against and/or ; 2) decreases the risk of developing clinical signs of and/or infection; 3) induces an immune response against and/or ; and 4) has a DOI against and/or of at least four months. The composition or vaccine as well as the combined -composition or vaccine each includes a bacterial component of inactivated bacteria and a suitable adjuvant. The combined -composition or vaccine further includes an amount of antigen. The vaccines can be administered to animals in any conventional manner. The amount of the dose for intramuscular administration is preferably less than 5 ml. The amount of and/or antigen in each dose should be enough to induce an immune response in the animal receiving the vaccine or composition and will preferably confer effective immunity against and decrease the risk of developing clinical signs resulting from and/or infection for a suitable duration of immunity.