Karen A Evans

20040242580, Dec 2, 2004

Oct 24, 2003

10/380435

Martha Kelly - Collegeville PA, US
Karen Evans - Harleysville PA, US
James Gallagher - Ambler PA, US
Mark Mulvihill - East Northport NY, US

A61K031/53
C 07D 4 9/02
C 07D 4 3/02

514/242000, 544/182000

This invention relates to dihydrotriazinones, triazinones and related compounds, compositions comprising such compounds and an agronomically acceptable carrier, and the use thereof as broad spectrum fungicides and insecticides. This invention also teaches methods of preparing these compounds as well as methods of using the compounds as fungicides and insecticides.

20050065033, Mar 24, 2005

Aug 21, 2003

10/645431

Richard Jacobson - Chalfont PA, US
Martha Kelly - Collegeville PA, US
Fiona Wehmeyer - Roslyn PA, US
Karen Evans - Harleysville PA, US

A01N025/26
A01N047/40
A01N035/00
A01N035/10

504343000, 504344000, 504348000, 564253000, 564271000

The present invention generally relates to methods of inhibiting ethylene responses in plants and plant materials, and particularly relates to methods of inhibiting various ethylene responses including plant maturation and degradation, by exposing plants to cyclopropene derivatives and compositions thereof wherein: 1) at least one substituent on the cyclopropene ring contains a carbocyclic or heterocyclic ring, or 2) . a substituent contains silicon, sulfur, phosphorous, or boron, or 3) least one substituent contains from one to four non-hydrogen atoms and at least one substituent contains more than four non-hydrogen atoms.

20070249670, Oct 25, 2007

Nov 4, 2005

11/718804

Karen Evans - Collegeville PA, US
Frank Coppo - Collegeville PA, US
Kate Dwornik - Durham NC, US
Jennifer Gale - Durham NC, US
Dulce Garrido - Durham NC, US
Yue Li - Collegeville PA, US
Mehul Patel - Collegeville PA, US
Francis Tavares - Durham NC, US
Stephen Thomson - Durham NC, US
Scott Dickerson - Durham NC, US
Andrew Peat - Durham NC, US
Steven Sparks - Durham NC, US
Pierette Banker - Durham NC, US
Joel Cooper - Durham NC, US

SMITHKLINE BEECHAM CORPORATION - Philadelphia PA

A61K 31/24
A61K 31/381
A61K 31/40
A61K 31/4164
A61K 31/445
A61K 31/47
C07C 229/72
C07D 207/16
C07D 211/18
C07D 215/38
C07D 233/64
C07D 333/50

514313000, 514319000, 514400000, 514423000, 514438000, 514443000, 514539000, 546162000, 546205000, 548334100, 548533000, 549057000, 560034000

The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.

20110190137, Aug 4, 2011

Apr 8, 2011

13/082545

Richard Martin Jacobson - Chalfont PA, US
Martha Jean Kelly - Collegeville PA, US
Fiona Linette Wehmeyer - Roslyn PA, US
Karen Anderson Evans - Harleysville PA, US

A01N 55/10
A01N 29/00
A01N 43/10
A01N 43/32
A01N 27/00
A01N 31/08
A01N 31/00
A01N 41/02
A01N 43/56
A01N 43/50
A01N 43/84
A01N 43/40
A01N 43/08
A01N 43/653
A01N 43/36
A01N 43/58
A01P 21/00

504193, 504356, 504289, 504293, 504357, 504354, 504349, 504350, 504280, 504275, 504326, 504224, 504248, 504294, 504254, 504273, 504283, 504236

The present invention generally relates to methods of inhibiting ethylene responses in plants and plant materials, and particularly relates to methods of inhibiting various ethylene responses including plant maturation and degradation, by exposing plants to cyclopropene derivatives and compositions thereof wherein: 1) at least one substituent on the cyclopropene ring contains a carbocyclic or heterocyclic ring, or 2) a substituent contains silicon, sulfur, phosphorous, or boron, or 3) least one substituent contains from one to four non-hydrogen atoms and at least one substituent contains more than four non-hydrogen atoms.

20210253528, Aug 19, 2021

Jul 8, 2019

16/973587

- Brentford, Middlesex, GB
Karen Anderson EVANS - Collegeville PA, US
Israil PENDRAK - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US

C07D 213/64
C07C 271/28
C07C 275/30
C07C 235/20
C07D 207/273
A61K 45/06
A61K 31/506

The invention is directed to substituted carbon-linked bicycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (X):

20210093619, Apr 1, 2021

Jun 7, 2018

16/619985

- Brentford, Middlesex, GB
Michael P. DEMARTINO - Collegeville PA, US
Karen Anderson EVANS - Collegeville PA, US
Biswajit KALITA - Yeshwanthpur, Bangalore, IN
Jeffrey M. RALPH - Collegeville PA, US

A61K 31/4439
A61K 45/06
C07C 233/41
A61K 31/165
A01N 1/02
C07D 213/65
A61K 31/44
A61K 31/444
C07D 401/12
C07D 305/08
A61K 31/337
A61K 31/4166
C07D 233/36
C07D 207/12
A61K 31/40
C07D 401/04
A61K 31/397
C07D 205/04
A61K 31/343
C07D 307/85
C07D 311/58
A61K 31/353
A61K 31/4035
C07D 209/44
A61K 31/451
C07D 211/18
C07D 401/14
C07D 207/273
C07D 211/46
A61K 9/48
A61K 9/00
A61K 9/20

The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula IIIQ:wherein X, a, b, C, D, L, L, R, R, R, R, R, R, z, z, z, and z are as defined herein; or salts thereof.The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

20200193046, Jun 18, 2020

Dec 9, 2019

16/707981

- Runnemede NJ, US
Karen EVANS - Glen Mills PA, US

SIELOX, LLC - Runnemede NJ

G06F 21/62
G08B 25/14
G05B 15/02
G08B 21/02

The present invention is related to systems and methods for identifying and reporting a crisis status. In at least one embodiment, the system comprises a central server; an administrative work station communicably coupled to the central server, wherein the administrative work station is accessible only by an authorized administrator; a database communicably coupled to the central server, the database including a floor plan of the area, wherein the database is accessible and modifiable by the authorized administrator at the administrative work station; and a remote device at a particular location in the area, the remote device communicably coupled to the central server, the remote device capable of communicating securely to the database the particular location of the remote device and the crisis status of the particular location.

20190194166, Jun 27, 2019

Jun 13, 2017

16/309121

- Brentford, Middlesex, GB
- London, Greater London, GB
María Lourdes Rueda BENEDE - Collegeville PA, US
Karen Anderson EVANS - Collegeville PA, US
David T. FOSBENNER - Collegeville PA, US
Bryan Wayne KING - Collegeville PA, US
Mei LI - Collegeville PA, US
Juan Ignacio LUENGO - Collegeville PA, US
William Henry MILLER - Collegeville PA, US
Alexander Joseph REIF - Collegeville PA, US
Stuart Paul ROMERIL - Collegeville PA, US
Stanley J. SCHMIDT - Collegeville PA, US
Roger J. BUTLIN - Manchester, GB
Kristen M. GOLDBERG - Manchester, GB
Allan M. JORDAN - Manchester, GB
Christopher S. KERSHAW - Manchester, GB
Ali RAOOF - Manchester, GB
Bohdan WASZKOWYCS - Manchester, GB

C07D 401/12
C07D 417/12
A61P 35/00
A61P 37/00

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar):wherein Y, X, X, R, R, R, Rand Rare as defined herein; or a pharmaceutically acceptable salt or prodrug thereof.The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.