US Patent:
20020072484, Jun 13, 2002
Inventors:
Susan Alters - Palo Alto CA, US
Karen Cheal - Mountain View CA, US
Aaron Kantor - San Carlos CA, US
International Classification:
C12Q001/68
G01N033/567
A61K031/00
US Classification:
514/001000, 435/007210, 435/006000
Abstract:
Novel biological markers indicative of the action of an anti-inflammatory or immunosuppressive drug can be used to evaluate drug efficacy and compare local and systemic drug effects. They can also aid in comparison of different drugs, doses, and delivery routes. The biological markers include cell populations, cell surface antigen expression levels, and soluble factor concentrations. Measurement values of the novel biomarkers were shown to change significantly in allergic, atopic asthmatic, and healthy subjects after administration of prednisone.