Kanagasabai Panchalingam

7632662, Dec 15, 2009

Jul 31, 2008

12/183609

Jay W. Pettegrew - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US
Richard J. McClure - Pittsburgh PA, US

C12P 21/02

435 701, 514548, 514556

Carnitines are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to produce longer chain fatty acid esters of carnitines such as polyunsaturated fatty acid esters including eicosapentaenoyl-L-carnitine and/or docosahexaenyl-L-carnitine in germinating plant seeds. The resulting products from the plant seeds are used as a natural nutritional source of powerful human antioxidants.

7700074, Apr 20, 2010

Aug 23, 2005

11/209318

Jay W. Pettegrew - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US

A61K 49/00
A61B 5/055
A61K 31/70
A61K 31/66
A61K 31/22
A61K 31/205

424 91, 424 93, 514 44, 514 75, 514546, 514556

Chronic alcoholism is a diverse and heterogeneous disorder that can be dichotomized into cognitively intact and cognitively impaired subgroups. At a molecular level, ethanol has been shown to have both acute and chronic effects on: Membrane biophysical properties, Membrane composition and metabolism, Protein phosphorylation, Lipid metabolic signaling, Lipoprotein transport of cholesterol. Actual molecular underpinnings are determined for cognitive impairment seen in some chronic alcoholism subjects including molecular/metabolic alterations of phospholipid and ganglioside metabolisms.

7815894, Oct 19, 2010

May 27, 2004

10/854894

Jay W. Pettegrew - Pittsburgh PA, US
Richard J. McClure - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US
Billy W. Day - Pittsburgh PA, US

A61K 51/00
A61M 36/14

424 177, 424 111, 424 165, 424 181, 424 185, 424 189, 424 91, 424 92, 424 93, 424 94

Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease. GPC is a membrane phospholipid metabolite that is capable of binding specifically to the β-turn of beta amyloid (Aβ) peptide. Compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging and/or positron emission tomography applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the diagnosis and assessment of the progression of Alzheimer's disease may be achieved.

8329142, Dec 11, 2012

Jul 23, 2008

12/178281

Jay W. Pettegrew - Pittsburgh PA, US
Richard J. McClure - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US

A61K 51/00
A61M 36/14

424 189, 424 111, 424 165, 424 181, 424 185, 424 91

Compounds, compositions and methods for the detection and diagnosis of Parkinson's disease. Derivative lycerophosphocholine (GPC) compounds are used as a detection and diagnostic aid to measure progression of Parkinson's disease by detecting GPC binding to α-synuclein. Derivative CPG compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging (MRI) and/or positron emission tomography (PET) applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the detection, diagnosis and assessment of the progression of Parkinson's disease may be achieved.

20060088614, Apr 27, 2006

Aug 5, 2005

11/198761

Jay Pettegrew - Pittsburgh PA, US
Samuel Gershon - Fox Chapel PA, US
Kanagasabai Panchalingam - Monroeville PA, US

A61K 31/22
A61K 36/28

424764000, 514546000

Acetyl--carnitine (ALCAR) and L-carntine (LCAR) are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to enhance LCAR and LCAR formation in germinating plant seeds. Metabolic fluxes are manipulated by germination in bioreactors to increase oxygen availability as well as provide an aseptic environment to alter carbohydrate consumption and feedback repress gluconeogenesis. Large shifts in sunflower seed fatty acid, phospholipid and high-energy metabolism change the germination environment and these metabolic changes lead to an approximate 1000-fold increase in natural LCAR and ALCAR production by the seeds. The resulting LCAR and ALCAR products from the seeds are used for treating mental health disorders including Alzheimer's disease, geriatric depression, non-geriatric depression and schizophrenia.

20060257842, Nov 16, 2006

Apr 21, 2006

11/409395

Jay Pettegrew - Pittsburgh PA, US
Thomas Glonek - Oak Park IL, US
Richard McClure - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US

A01N 1/02
A01N 1/00

435001100, 435002000

The cryopreservation media utilizes naturally occurring endogenous molecules and their chemical derivatives which act as osmotically active cryopreservative agents as well as molecules which insert into and protect specific regions of cellular membranes, lead to membrane repair, maintain normal cellular levels of energy metabolites, and act as antioxidants. Cryoperserved cells can be returned to a pre- cryopreservation state without damaging the cells resulting in a very high survival rate.

20100010336, Jan 14, 2010

Jul 23, 2009

12/508559

Jay W. PETTEGREW - Pittsburgh PA, US
Kanagasabai Panchalingam - Monroeville PA, US

A61B 5/055

600410

A method and system for medical imaging of neuropsychiatric disorders including attention deficit hyperactivity disorder (ADHD), autism, and schizophrenia. Noninvasive, in vivo methods identify novel brain molecular biomarkers of normal neurodevelopment in order to determine molecular underpinnings of abnormal neurodevelopment. The described brain molecular biomarkers will aid in the presymptomatic diagnosis of neuropsychiatric disorders which begin in childhood and adolescence, such as ADHD, autism, and schizophrenia.