Inventors:
Phillip Lograsso - Carlsbad CA, US
Julio Hawkins - Summit NJ, US
Jean Marie Lisnock - Middletown NJ, US
International Classification:
C12Q001/68
C07H021/04
C12N009/12
US Classification:
435/006000, 435/069100, 435/194000, 435/320100, 435/325000, 536/023200
Abstract:
Disclosed herein are two newly identified enzymes—mitogen-activated protein kinase-activated protein kinase-2, each comprising a sequence of nucleotides as set forth in SEQ ID NOs: 1 and 3. Each of the herein disclosed enzymes is a serine/threonine signal transduction kinase that is phosphorylated and activated by Erks and p38 MAPK in vitro. Also disclosed, inter alia, are cells containing the recombinant nucleic acid molecules; antisense constructs thereto; antibodies specific for each of the disclosed proteins; methods for using the novel nucleic acid molecules and their gene products including kits containing the same.
