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Julio Camarero Phones & Addresses

  • Los Angeles, CA

Publications

Us Patents

Compositions And Methods For The Rapid Biosynthesis And In Vivo Screening Of Biologically Relevant Peptides

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US Patent:
20120283136, Nov 8, 2012
Filed:
Jun 23, 2010
Appl. No.:
13/379340
Inventors:
Julio A. Camarero - Los Angeles CA, US
International Classification:
C40B 30/06
G01N 21/64
G01N 21/76
C12N 1/21
C12N 5/10
C12N 1/19
C12N 1/15
C12N 1/13
C12Q 1/68
C12N 15/63
US Classification:
506 10, 435 613, 4353201, 435325, 435348, 435419, 435363, 4352542, 43525411, 435354, 435353, 435350, 435349, 435366, 4352572, 43525231, 43525233, 4352523, 435351
Abstract:
This invention provides new combinatorial approaches for the biosynthesis and screening of cyclic peptides inside living cells. These novel approaches are useful for finding biologically relevant molecules, e.g., those able to inhibit the cytotoxicity of Anthrax Edema Factor. Key to this ‘living combinatorial’ approach is the use of a living cell as a micro-chemical factory for both synthesis and screening of potential inhibitors for a given molecular recognition event.

Proteolically Resistant Cyclotides With Angiotensin 1-7 Like Activity

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US Patent:
20190359674, Nov 28, 2019
Filed:
Dec 26, 2018
Appl. No.:
16/232985
Inventors:
Julio A. Camarero Palao - San Gabriel CA, US
Teshome L. Aboye - Los Angeles CA, US
Kathleen E. Rodgers - Los Angeles CA, US
International Classification:
C07K 14/575
C07K 14/00
Abstract:
Described herein is a novel cyclotide able to activate the unique receptor of angiotensin-(1-7) (AT1-7), the MAS1 receptor. This cyclotide may be used in the treatment of cancer and myocardial infarction.

Synthetic Apolipoproteins, And Related Compositions Methods And Systems For Nanolipoprotein Particles Formation

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US Patent:
20180186860, Jul 5, 2018
Filed:
Sep 9, 2016
Appl. No.:
15/744754
Inventors:
- LIVERMORE CA, US
Julio A. CAMARERO - SAN GABRIEL CA, US
International Classification:
C07K 14/775
C07K 1/00
C07K 1/107
C07K 1/113
Abstract:
Synthetic apolipoproteins based on native/naturally occurring homolog proteins can be prepared using solid-phase peptide synthesis approaches combined with native chemical ligation methods to create analogs of full length apolipoproteins. The chemical synthesis is expected to allow introduction of non-natural amino acids, e.g., α,α′-dialkyl amino acids, with a periodicity that encourages both helix formation and amphipathicity. Such apolipoprotein analogs are expected to encourage, in some embodiments, facile and more complete NLP formation, enabling consideration of full spectrum of nanoparticle-based biotechnology applications ranging from therapeutic sequestration and delivery to energy/biofuel production to biopolymer production.

Proteolically Resistant Cyclotides With Angiotensin 1-7 Like Activity

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US Patent:
20170218040, Aug 3, 2017
Filed:
Feb 1, 2017
Appl. No.:
15/422376
Inventors:
Julio A. Camarero Palao - San Gabriel CA, US
Teshome L. Aboye - Los Angeles CA, US
Kathleen E. Rodgers - Los Angeles CA, US
International Classification:
C07K 14/575
C07K 14/00
Abstract:
Described herein is a novel cyclotide able to activate the unique receptor of angiotensin-(1-7) (AT1-7), the MAS1 receptor. This cyclotide may be used in the treatment of cancer and myocardial infarction.
Julio C Camarero from Los Angeles, CADeceased Get Report