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Julia O Hegge

from Monona, WI
Age ~65
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Also known as:
Julia D Hegge, Juiia Hegge, Julia O'Hegg, Julia E
Phone and address:
205 Panther Trl, Madison, WI 53716
(608) 221-2603
Related to:
Wendy M Labine, 57Jane E Hegge, 37John D HeggeMichael J Hegge, 64Jane E Hegge, 34Emily A Hegge, 37Carl R Matthews Barr, 36
Connected to:
Jeremy E Hegge, 48Joey Hegge, 47Valorey H Heggedahl, 66Jack R Heggeland, 90Julie K Heggem, 51Ronald P Heggem, 74Sharon L Heggeman, 63Jill M Heggemeier, 42Lowell G Heggemeyer, 58Carolyn H Heggen, 79

Julia Hegge Phones & Addresses

  • 205 Panther Trl, Madison, WI 53716 (608) 221-2603
  • Monona, WI

Work

Company: Arrowhead madison Nov 2011 Position: Scientist

Education

Degree: Bachelors, Bachelor of Science School / High School: Edgewood College Specialities: Biology

Skills

Biotechnology

Emails

e***[email protected]

Industries

Biotechnology

Resumes

Resumes

Julia Hegge Photo 1

Scientist

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Location:
302 Victorian Way, Enterprise, AL 36330
Industry:
Biotechnology
Work:
Arrowhead Madison
Scientist
Roche Madison 2008 - 2011
Scientist
Mirus Bio Llc 2000 - 2008
Scientist
Education:
Edgewood College
Bachelors, Bachelor of Science, Biology
Skills:
Biotechnology

Publications

Us Patents

Nucleic Acid Injected Into Hapatic Vein Lumen And Delivered To Primate Liver

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US Patent:
7144869, Dec 5, 2006
Filed:
Dec 5, 2002
Appl. No.:
10/310398
Inventors:
Jon A. Wolff - Madison WI, US
Julia Hegge - Monona WI, US
James E. Hagstrom - Middleton WI, US
Vladimir G. Budker - Middleton WI, US
Assignee:
Mirus Bio Corporation - Madison WI
International Classification:
A61K 31/70
C12N 15/74
US Classification:
514 44, 4353201, 435455, 536 231, 536 245
Abstract:
Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.

Devices And Processes For Distribution Of Genetic Material To Mammalian Limb

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US Patent:
7214369, May 8, 2007
Filed:
May 5, 2003
Appl. No.:
10/429478
Inventors:
Jon A. Wolff - Madison WI, US
Vladimir G. Budker - Middleton WI, US
James E. Hagstrom - Middleton WI, US
Julia Hegge - Monona WI, US
Vladimir Subbotin - Madison WI, US
Assignee:
Mirus Bio Corporation - Madison WI
International Classification:
A01N 63/00
A61K 48/00
US Classification:
424 932
Abstract:
A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.

Process For Delivery Of Polynucleotides To The Prostate

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US Patent:
7435723, Oct 14, 2008
Filed:
Oct 6, 2003
Appl. No.:
10/680742
Inventors:
James E. Hagstrom - Middleton WI, US
Mark Noble - Monona WI, US
Julia Hegge - Monona WI, US
Vladimir G. Budker - Middleton WI, US
Assignee:
Mirus Bio Corporation - Madison WI
International Classification:
A61K 48/00
A01N 63/00
US Classification:
514 44, 424 932
Abstract:
Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the polynucleotide to the cell.

Intravascular Delivery Of Nucleic Acid

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US Patent:
7473419, Jan 6, 2009
Filed:
Nov 7, 2005
Appl. No.:
11/268276
Inventors:
Jon A. Wolff - Madison WI, US
James E. Hagstrom - Middleton WI, US
Hans Herweijer - Madison WI, US
Vladimir G. Budker - Middleton WI, US
Julia Hegge - Monona WI, US
Assignee:
Roche Madison Inc. - Madison WI
International Classification:
A01N 63/00
A61K 48/00
US Classification:
424 932, 435455, 435456, 514 44
Abstract:
Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.

Nucleic Acid Injected Into Hepatic Vein Lumen

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US Patent:
7547683, Jun 16, 2009
Filed:
Oct 10, 2006
Appl. No.:
11/539900
Inventors:
Jon A. Wolff - Madison WI, US
Tatyana Budker, legal representative - Middleton WI, US
Julia Hegge - Monona WI, US
James E. Hagstrom - Middleton WI, US
Assignee:
Roche Madison, Inc. - Madison WI
International Classification:
A01N 43/04
C12N 15/00
US Classification:
514 44, 435 691, 435455
Abstract:
Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.

Delivery Of Molecules And Complexes To Mammalian Cells In Vivo

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US Patent:
7589059, Sep 15, 2009
Filed:
Jul 28, 2003
Appl. No.:
10/628792
Inventors:
Jon A. Wolff - Madison WI, US
Vladimir G. Budker - Middleton WI, US
Hans Herweijer - Madison WI, US
James E. Hagstrom - Middleton WI, US
Sean D. Monahan - Madison WI, US
Julia Hegge - Monona WI, US
Vladimir Subbotin - Madison WI, US
Assignee:
Roche Madison Inc. - Madison WI
International Classification:
A61K 38/00
A61K 38/08
C07K 14/00
US Classification:
514 2, 514 8, 514 12, 530300, 530350
Abstract:
Disclosed is a system for providing in vivo delivery of molecules or complexes to extravascular mammalian cells using an intravascular administration route. The molecules or complexes are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate transiently increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the molecule to the cell.

Process For Delivering Sirna To Cardiac Muscle Tissue

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US Patent:
7781415, Aug 24, 2010
Filed:
Feb 3, 2004
Appl. No.:
10/770588
Inventors:
Hans Herweijer - Madison WI, US
Julia Hegge - Monona WI, US
Jon A. Wolff - Madison WI, US
David L. Lewis - Madison WI, US
Assignee:
Roche Madison Inc. - Madison WI
International Classification:
A61K 48/00
US Classification:
514 44, 536 245, 536 2431, 536 241
Abstract:
A process for delivering a polynucleotide to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a polynucleotide into a blood vessel and increasing permeability of the blood vessel to the polynucleotide. The polynucleotide can be a small interfering RNA or microRNA and inhibit gene expression in the cell.

Intravenous Delivery Of Polynucleotides To Cells In Mammalian Limb

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US Patent:
7803782, Sep 28, 2010
Filed:
May 27, 2004
Appl. No.:
10/855175
Inventors:
James E. Hagstrom - Middleton WI, US
Julia Hegge - Monona WI, US
Hans Herweijer - Brooklyn WI, US
Jon A. Wolff - Madison WI, US
Assignee:
Roche Madison Inc. - Madison WI
International Classification:
A61K 48/00
A61M 31/00
US Classification:
514 44, 604500
Abstract:
An intravenous delivery method is described that enables delivery of polynucleotides to extravascular cells of a mammalian limb. The method involves the injection of polynucleotides into a distal vein of a limb that is transiently occluded. Polynucleotide delivery is facilitated by rapid injection in sufficient volume to enable extravasation of the solution into surrounding tissue.
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Julia O Hegge from Monona, WI, age ~65 Get Report