Inventors:
Eric M. Weisser - Somerset NJ
Judith K. Whaley - Belle Mead NJ
Amos E. Enabosi - Piscataway NJ
Himanshu Shah - Branchburg NJ
Pankaj Rege - Monmouth Junction NJ
Assignee:
National Starch and Chemical Investment Holding Corporation - New Castle DE
International Classification:
A61K 914
US Classification:
424464, 424465, 424489, 514777, 514778
Abstract:
This invention relates to a method of using compressible polysaccharides having a tap density of less than 0. 4 g/ml as a filler/binder for tablets prepared by direct compression, excipient blends including said polysaccharides, a method of tableting an active ingredient therein from the excipient blends and the tablets produced therefrom. More particularly, this invention relates to the use of low-density starches as binders for tablets prepared by direct compression, excipient blends, and methods of tableting an active ingredient therein from such starches. Further, this invention describes a starch-based excipient composition having a tap density of less than 0. 4 g/ml, which has excellent moisture resistance.