Inventors:
Judit Jakus - Silver Spring MD
Myung H. Park - Potomac MD
Edith C. Wolff - Bethesda MD
John E. Folk - Derwood MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
International Classification:
C07C27904
A61K 31155
Abstract:
Compositions and methods for the treatment of mammalian cells to inhibit cell growth, especially for inhibiting the proliferative cell growth associated with malignant and non-malignant disease, are provided. More particularly, a deoxyhypusine synthase inhibitor, typically, a mono- or bisguanyl diamine or polyamine, is administered to the cells. Also provided by this invention are diagnostic methods and kits for screening the cells of a patient to determine the effect of the deoxyhypusine synthase inhibitor on proliferation of the cells.