Joseph G Vockley

6974667, Dec 13, 2005

Jun 14, 2001

09/880107

Darci T. Horne - Gaithersburg MD, US
Uwe Scherf - Gaithersburg MD, US
Joseph Vockley - Damascus MD, US

Gene Logic, Inc. - Gaithersburg MD

C12Q001/68
C12P019/34
C07H021/04

435 6, 435 911, 536 231, 536 243

The present invention identifies the global changes in gene expression associated with liver cancer by examining gene expression in tissue from normal liver, metastatic malignant liver and hepatocellular carcinoma. The present invention also identifies expression profiles which serve as useful diagnostic markers as well as markers that can be used to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.

20040033502, Feb 19, 2004

Jun 12, 2003

10/240425

Amanda Williams - Gaithersburg MD, US
Joseph Boland - Gaithersburg MD, US
Reginald Lord - Gaithersburg MD, US
Christopher Alvares - Gaithersburg MD, US
Jon Wetzel - Gaithersburg MD, US
Uwe Scherf - Gaithersburg MD, US
Joseph Vockley - Gaithersburg MD, US

C12Q001/68
A61K031/00

435/006000, 514/001000

The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention also concerns the promoter of said gene, the gene coding for protein 763, protein 763 and uses thereof for identifying potential biological targets for novel fungicide molecules and for isolating genes coding for proteins controlling biochemical functions essential to the pathogenesis of the fungus with respect to rice and barley. The invention further concerns compounds inhibiting pathogenesis of fungi related to the expression of gene 763.

20050050101, Mar 3, 2005

Jan 23, 2004

10/762763

Joseph Vockley - Damascus MD, US
Gregory Eley - Springfield VA, US

G06F007/00

707104100

Identifying genomic sequences and oligonucleotide sequences unique to a set of organisms. Methods include obtaining genomic data characteristic of the set; formatting the data into at least one query-length sequence, each query-length sequence being of a format compatible with a similarity search engine. Searching a selected genomic database using the query and the similarity search engine. Then parsing the results of the search for those sequences showing uniqueness to the set.

57802866, Jul 14, 1998

Aug 20, 1996

8/700186

Patrick J. Dillon - Gaithersburg MD
Joseph G. Vockley - Downingtown PA

SmithKline Beecham Corporation - Philadelphia PA
Human Genome Sciences Inc. - Rockville MD

C12N 978

435227

The invention relates to Arginase II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.