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Joseph W Sulner

from Paramus, NJ
Age ~78
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Also known as:
Sharon B Sulner, Joe W Sulner
Phone and address:
330 Bullard Ave, Paramus, NJ 07652
(201) 483-8062
Related to:
Sharon B Sulner, 76Beth M Sulner, 47Fe G Uriarte, 85Robert V Uriarte, 54
Connected to:
Tracey E Sulo, 51Christina Sulock, 46Kelsey M Suloff, 40Corinne D Sulok, 41Stephanie A Sulok, 49Randy P Sulon, 67Lorri Sulpizio, 49Terry L Sulpizio, 77Gina M Sulprizio, 72Stephanie R Sulpy, 63

Joseph Sulner Phones & Addresses

  • 330 Bullard Ave, Paramus, NJ 07652 (201) 483-8062 (201) 967-8332
  • Rutherford, NJ
  • Whitehouse Station, NJ
  • Palisades Park, NJ

Publications

Us Patents

Purification And Stabilization Of Peptide And Protein Pharmaceutical Agents

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US Patent:
6652885, Nov 25, 2003
Filed:
Aug 20, 2002
Appl. No.:
10/224761
Inventors:
Solomon S. Steiner - Mount Kisco NY
Rodney J. Woods - New Hampton NY
Joseph W. Sulner - Paramus NJ
Assignee:
MannKind Corporation - Danbury CT
International Classification:
A61K 914
US Classification:
424489, 424499, 424490, 424491, 424434, 514 1, 514 2, 514 3
Abstract:
Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal one or more impurities, i. e. undesirable components, from the peptide or protein. In a preferred embodiment, a peptide, such as insulin, containing one or more impurities, e. g. , zinc ions, is entrapped in diketopiperazine to form a precipitate of peptide/diketopiperazine/impurity, which is then washed with a solvent for the impurity to be removed, which is a nonsolvent for the diketopiperazine and a nonsolvent for the peptide. Formulations and methods also are provided for the improved transport of active agents across biological membranes, resulting for example in a rapid increase in blood agent concentration. The formulations include microparticles formed of (i) the active agent, which may be charged or neutral, and (ii) a transport enhancer that masks the charge of the agent and/or that forms hydrogen bonds with the target biological membrane in order to facilitate transport. In a preferred embodiment, insulin is administered via the pulmonary delivery of microparticles comprising fumaryl diketopiperazine and insulin in its biologically active form.

Method For Delivery Of Monomeric Or Dimeric Insulin Complexed To Diketopiperazine Microparticles

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US Patent:
7648960, Jan 19, 2010
Filed:
Nov 21, 2003
Appl. No.:
10/719734
Inventors:
Solomon S. Steiner - Mount Kisco NY, US
Rodney J. Woods - New Hampton NY, US
Joseph W. Sulner - Paramus NJ, US
Assignee:
MannKind Corporation - Valencia CA
International Classification:
A61K 38/28
A61K 38/00
A61K 9/00
A61K 9/14
US Classification:
514 3, 514 2, 424489, 424499, 424 46
Abstract:
Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal of one or more impurities from the peptide or protein. Formulations and methods also are provided for the improved transport of active agents across biological membranes, resulting for example in a rapid increase in blood agent concentration. The formulations include microparticles formed of (i) the active agent, which may be charged or neutral, and (ii) a transport enhancer that masks the charge of the agent and/or that forms hydrogen bonds with the target biological membrane in order to facilitate transport. In one embodiment insulin is administered via the pulmonary delivery of microparticles comprising fumaryl diketopiperazine and insulin in its biologically active form. This method of delivering insulin results in a rapid increase in blood insulin concentration that is comparable to the increase resulting from intravenous delivery.

Methods And Compositions For Delivering Peptides

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US Patent:
7943178, May 17, 2011
Filed:
Dec 10, 2009
Appl. No.:
12/635380
Inventors:
Solomon S. Steiner - Mount Kisco NY, US
Rodney J. Woods - New Hampton NY, US
Joseph W. Sulner - Paramus NJ, US
Assignee:
MannKind Corporation - Valencia CA
International Classification:
A61K 9/14
A61K 9/19
A61K 9/00
A61K 38/00
A61K 38/02
A61K 38/16
US Classification:
424489, 424 46, 514 2, 514 3, 514 12, 514866
Abstract:
Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal one or more impurities, from the peptide or protein. Formulations and methods also are provided for the improved transport of active agents across biological membranes, resulting for example in a rapid increase in blood agent concentration. The formulations include microparticles formed of (i) the active agent, which may be charged or neutral, and (ii) a transport enhancer that masks the charge of the agent and/or that forms hydrogen bonds with the target biological membrane in order to facilitate transport. In one embodiment, insulin is administered via the pulmonary delivery of microparticles comprising fumaryl diketopiperazine and insulin in its biologically active form. This method of delivering insulin results in a rapid increase in blood insulin concentration that is comparable to the increase resulting from intravenous delivery.

Methods And Compositions For Delivering Peptides

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US Patent:
8389470, Mar 5, 2013
Filed:
Jan 5, 2011
Appl. No.:
12/985197
Inventors:
Solomon S. Steiner - Mount Kisco NY, US
Rodney J. Woods - New Hampton NY, US
Joseph W. Sulner - Paramus NJ, US
Assignee:
MannKind Corporation - Valencia CA
International Classification:
A61K 9/14
A61K 38/28
US Classification:
514 59, 514866, 424 46, 424489
Abstract:
Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal one or more impurities, from the peptide or protein. Formulations and methods also are provided for the improved transport of active agents across biological membranes, resulting for example in a rapid increase in blood agent concentration. The formulations include microparticles formed of (i) the active agent, which may be charged or neutral, and (ii) a transport enhancer that masks the charge of the agent and/or that forms hydrogen bonds with the target biological membrane in order to facilitate transport. In one embodiment, insulin is administered via the pulmonary delivery of microparticles comprising fumaryl diketopiperazine and insulin in its biologically active form. This method of delivering insulin results in a rapid increase in blood insulin concentration that is comparable to the increase resulting from intravenous delivery.

Potentiation Of Glucose Elimination

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US Patent:
20070020191, Jan 25, 2007
Filed:
Jan 10, 2006
Appl. No.:
11/329686
Inventors:
Anders Boss - Princeton NJ, US
Solomon Steiner - Mount Kisco NY, US
Rodney Woods - New Hampton NY, US
Joseph Sulner - Paramus NJ, US
Assignee:
MannKind Corporation - Valencia CA
International Classification:
A61K 38/28
A61L 9/04
US Classification:
424045000, 514003000
Abstract:
Methods related to the treatment of diabetes and improving the efficiency of insulin utilization are provided. The method enables effective control of prandial glucose levels while reducing the risk of postprandial hypoglycemia. In particular, methods of potentiating the activity of endogenous insulin in type 2 diabetics and exogenous long-acting insulin in diabetics requiring basal insulin replacement are provided.

Repair Of Tympanic Membrane Using Placenta Derived Collagen Biofabric

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US Patent:
20070038298, Feb 15, 2007
Filed:
Jun 29, 2006
Appl. No.:
11/479801
Inventors:
Joseph Sulner - Paramus NJ, US
Janice Smiell - Morristown NJ, US
Sharon Bourke - Piscataway NJ, US
Patricia Murphy - Hillsborough NJ, US
International Classification:
A61F 2/18
US Classification:
623010000, 623023720
Abstract:
The present invention provides a method of repairing a tympanic membrane deformity, such as a tympanic membrane perforation, commonly referred to as tympanoplasty or myringoplasty, using a collagen biofabric. The collagen biofabric is preferably laminated. The invention further provides kits comprising one or more pieces of collagen biofabric, for example laminated collagen biofabric, for the repair of a tympanic membrane.

Method Of Drug Formulation Based On Increasing The Affinity Of Crystalline Microparticle Surfaces For Active Agents

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US Patent:
20100278924, Nov 4, 2010
Filed:
Jul 6, 2010
Appl. No.:
12/830557
Inventors:
Keith A. Oberg - Valencia CA, US
Joseph Sulner - Paramus NJ, US
Assignee:
MANNKIND CORPORATION - Valencia CA
International Classification:
A61K 9/18
A61K 38/27
A61K 38/28
A61K 38/26
A61K 38/29
A61K 39/395
A61K 38/22
A61K 39/44
A61P 35/00
A61P 5/50
A61P 5/18
A61P 3/00
B05D 3/00
US Classification:
424491, 514 113, 514 59, 514 72, 514 118, 4241411, 514 49, 427 214
Abstract:
Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.

Methods And Compositions For Delivering Peptides

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US Patent:
20130143801, Jun 6, 2013
Filed:
Jan 30, 2013
Appl. No.:
13/754698
Inventors:
Solomon S. Steiner - Mount Kisco NY, US
Rodney J. Woods - New Hampton NY, US
Joseph W. Sulner - Paramus NJ, US
International Classification:
A61K 9/00
US Classification:
514 59
Abstract:
Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal one or more impurities, from the peptide or protein. Formulations and methods also are provided for the improved transport of active agents across biological membranes, resulting for example in a rapid increase in blood agent concentration. The formulations include microparticles formed of (i) the active agent, which may be charged or neutral, and (ii) a transport enhancer that masks the charge of the agent and/or that forms hydrogen bonds with the target biological membrane in order to facilitate transport. In one embodiment, insulin is administered via the pulmonary delivery of microparticles comprising fumaryl diketopiperazine and insulin in its biologically active form. This method of delivering insulin results in a rapid increase in blood insulin concentration that is comparable to the increase resulting from intravenous delivery.
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Joseph W Sulner from Paramus, NJ, age ~78 Get Report