Inventors:
David Thomas Connor - Ann Arbor MI
Joseph Peter Menetski - Dexter MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 3118
Abstract:
The present invention provides compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of diseases whose treatment benefits from the inhibition of phosphodiesterase (PDE-IV) or Tumor Necrosis Factor (TNF) including asthma, allergic diseases, rheumatoid arthritis, osteoarthritis, septic shock. The compounds provided by this invention have formula (I) wherein R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 are as defined herein.