Jorg P Thommes

8608960, Dec 17, 2013

May 21, 2007

11/751147

Jorg Thommes - San Diego CA, US
Alan M. Sonnenfeld - San Diego CA, US
John P. Pieracci - San Diego CA, US
Lynn Conley - Carlsbad CA, US
Marc Bisschops - Leiden, NL
Maarten Pennings - Lieden, NL

Biogen Idec Inc. - Weston MA

B01D 15/08

2101982, 210635, 210656, 210659

Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods. Also provided are purified immunoreactive compounds prepared using the SMB methods and apparatus and methods of treatment with the purified immunoreactive compounds.

20040241878, Dec 2, 2004

Sep 12, 2003

10/661086

Jorg Thommes - San Diego CA, US
Alan Sonnenfeld - San Diego CA, US
John Pieracci - San Diego CA, US
Lynn Conley - Escondido CA, US
Marc Bisschops - Breda, NL
Maarten Pennings - The Hague, NL

G01N033/558

436/514000

Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods. Also provided are purified immunoreactive compounds prepared using the SMB methods and apparatus and methods of treatment with the purified immunoreactive compounds.

20100310548, Dec 9, 2010

Oct 15, 2008

12/738091

Ping Yeh - Solana Beach CA, US
Jorg Thommes - San Diego CA, US
Wolfgang Noe - San Diego CA, US
Wolfgang Berthold - Solana Beach CA, US

Biogen Idec MA Inc. - Cambridge MA

A61K 39/395
C12P 1/00
C12P 21/00
A61P 37/00

4241301, 435 41, 435 711

The present invention is directed to methods of isolating and purifying protein from a bioreactor process. The invention relates to employing a protein phase separation methodology to isolate or purify protein product in the forms of solid, semi-solid, or suspension during a protein manufacturing purification process as a stable storage intermediate. This approach is designed to allow the isolated protein product (purified or partially purified) to be stored over an extended period of time prior to further protein purification steps.

20110147312, Jun 23, 2011

Jan 23, 2009

12/863955

Paul Cunnien - Cary NC, US
Joydeep Ganguly - Boston MA, US
Basav Ghosh - Cary NC, US
Asif Ladiwala - San Diego CA, US
Robert Song - Scituate MA, US
Jorg Thommes - San Diego CA, US

Biogen Idec MA Inc. - Weston MA

B01D 15/08
B01D 35/14

210656, 210 85

The present invention provides automated systems and methods for monitoring column performance in process chromatography, and applications thereof. In an embodiment, column performance is monitored by generating a plurality of process values such as, for example, conductivity values or pH values with a detector during a chromatography step transition between a first mobile phase liquid and a second mobile phase liquid. The process values are transformed to form transformed process values in which noise present in the process values is suppressed. Column performance parameters are calculated based on the transformed process values and displayed during movement of the second mobile phase liquid through the chromatography column. The displayed performance parameters enable an operator to make a determination, for example, regarding the quality of the chromatography column packing and whether to continue the chromatography process or stop the chromatography process until the chromatography column can be repacked or replaced.

20140067308, Mar 6, 2014

Sep 30, 2013

14/041318

Joydeep GANGULY - Raleigh NC, US
Basav GHOSH - Cary NC, US
Asif LADIWALA - San Diego CA, US
Robert SONG - Scituate MA, US
Jorg THOMMES - San Diego CA, US

Biogen Idec MA Inc. - Cambridge MA

G01N 33/00

702100

The present invention provides automated systems and methods for monitoring column performance in process chromatography, and applications thereof. In an embodiment, column performance is monitored by generating a plurality of process values such as, for example, conductivity values or pH values with a detector during a chromatography step transition between a first mobile phase liquid and a second mobile phase liquid. The process values are transformed to form transformed process values in which noise present in the process values is suppressed. Column performance parameters are calculated based on the transformed process values and displayed during movement of the second mobile phase liquid through the chromatography column. The displayed performance parameters enable an operator to make a determination, for example, regarding the quality of the chromatography column packing and whether to continue the chromatography process or stop the chromatography process until the chromatography column can be repacked or replaced.