Michael Zachariou - Walnut Creek CA Jonathan Mazer - Winters CA Hyun J. Park - Los Angeles CA Charles Olson - Moraga CA
Assignee:
Bayer Corporation - Berkeley CA
International Classification:
C07K 1700 C07K 100 C12P 2100 A61K 3514
US Classification:
530412
Abstract:
A chemiluminescence-based gel assay may be used as an indicator of fermenter health. The assay is performed using a sample of fermentation medium essentially directly from the fermenter (with no need for complicated purification of the sample before performing the assay). Results from the assay may be correlated with the final product purification yield of a given protein/purification protocol system. This may then be used as a predictor of purification yield before actually performing the purification.