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Jonathan W Lockner

from San Diego, CA
Age ~45
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Also known as:
Johnathan W Lockner
Phone and address:
10750 Sabre Hill Dr, San Diego, CA 92128
(858) 391-9419
Related to:
Richard W Lockner, 72Christopher J Lockner, 64Alyssa J Cruz, 42Jonathan A Cruz, 39Julie A Cruz, 68Randall J Lockner, 50Linda G Lockner, 63Kelly L Kloiber, 52Danny E Cruz, 69Aaron LocknerDonald W Vancas, 83Aaron C Lockner, 38Phyllis S Vancas, 74
Connected to:
Adam C Lockner, 72Amy L Lockner, 65Jeannette Lockner, 58Kendra Lockner, 35Robert Lockner, 53Eric C Locko, 43Andrew J Lockrem, 34Carin L Lockrem, 77Peter J Lockrem, 72

Jonathan Lockner Phones & Addresses

  • 10750 Sabre Hill Dr, San Diego, CA 92128 (858) 391-9419
  • 10750 Sabre Hill Dr UNIT 147, San Diego, CA 92128
  • Kalamazoo, MI
  • Minooka, IL
  • Plainfield, IL
  • Hammond, IN
  • Orange Park, FL
  • Urbana, IL

Work

Company: Pfizer global research & development - San Diego, CA Aug 2003 Position: Research associate

Education

School / High School: The Scripps Research Institute- La Jolla, CA 2006 Specialities: PhD in Chemistry

Skills

Organic Synthesis • Chemistry • Medicinal Chemistry • Organic Chemistry • Nmr • Lc Ms • Small Molecules • Drug Design • Laboratory • Drug Discovery • Hplc • Mass Spectrometry • Biochemistry • Life Sciences • Organometallic Chemistry • Peptide Synthesis • Synthetic Organic Chemistry • Purification • Nmr Spectroscopy • Lead Change • Scifinder • Natural Products • Chemical Biology • Protein Chemistry • Immunology • Cancer

Languages

English • Spanish

Interests

Children • Soccer • Education • Poverty Alleviation • Science and Technology • Running • Book Manuscript Editing/Proofreading • Health

Industries

Research

Resumes

Resumes

Jonathan Lockner Photo 1

Visiting Scientist

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Location:
10750 Sabre Hill Dr, San Diego, CA 92128
Industry:
Research
Work:
Palomar College
Adjunct Faculty
Point Loma Nazarene University
Adjunct Faculty
San Diego Miramar College
Adjunct Faculty
California Institute For Biomedical Research (Calibr) Jun 2015 - Oct 2016
Postdoctoral Fellow
The Scripps Research Institute Nov 2011 - May 2015
Research Associate
Education:
Scripps Research Jan 1, 2006 - 2011
Doctorates, Doctor of Philosophy, Chemistry University of Illinois at Urbana - Champaign Jan 1, 1997 - 2001
Bachelors, Bachelor of Science, Chemistry Plainfield High School 1997
Skills:
Organic Synthesis
Chemistry
Medicinal Chemistry
Organic Chemistry
Nmr
Lc Ms
Small Molecules
Drug Design
Laboratory
Drug Discovery
Hplc
Mass Spectrometry
Biochemistry
Life Sciences
Organometallic Chemistry
Peptide Synthesis
Synthetic Organic Chemistry
Purification
Nmr Spectroscopy
Lead Change
Scifinder
Natural Products
Chemical Biology
Protein Chemistry
Immunology
Cancer
Interests:
Children
Soccer
Education
Poverty Alleviation
Science and Technology
Running
Book Manuscript Editing/Proofreading
Health
Languages:
English
Spanish
Jonathan Lockner Photo 2

Jonathan Lockner San Diego, CA

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Work:
Pfizer Global Research & Development
San Diego, CA
Aug 2003 to Jul 2006
Research Associate
Pharmacia Corporation
Kalamazoo, MI
Jun 2001 to Aug 2003
Research Associate
Education:
The Scripps Research Institute
La Jolla, CA
2006 to 2011
PhD in Chemistry
University of Illinois
Urbana-Champaign, IL
1997 to 2001
BS in Chemistry

Publications

Us Patents

Pharmacophore For Trail Induction

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US Patent:
20200283440, Sep 10, 2020
Filed:
Apr 14, 2020
Appl. No.:
16/848032
Inventors:
- La Jolla CA, US
Nicholas T. JACOB - San Diego CA, US
Jonathan W. LOCKNER - San Diego CA, US
Assignee:
THE SCRIPPS RESEARCH INSTITUTE - La Jolla CA
International Classification:
C07D 471/14
A61K 31/519
Abstract:
There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein.

Pharmacophore For Trail Induction

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US Patent:
20190284188, Sep 19, 2019
Filed:
Mar 20, 2019
Appl. No.:
16/359633
Inventors:
- La Jolla CA, US
Nicholas T. Jacob - San Diego CA, US
Jonathan W. Lockner - San Diego CA, US
International Classification:
C07D 471/14
A61K 31/519
Abstract:
There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein.

Enantiopure Haptens For Nicotine Vaccine Development

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US Patent:
20180086820, Mar 29, 2018
Filed:
Nov 21, 2017
Appl. No.:
15/819283
Inventors:
- La Jolla CA, US
Jonathan W. Lockner - San Diego CA, US
International Classification:
C07K 16/16
A61K 39/385
C07D 401/04
Abstract:
The invention provides chiral haptens (−)-3′-AmNic and (−)-N4N for use in generating antibodies in a patient specific for (−)-nicotine. The haptens can be conjugated to suitable carrier proteins and administered as an antigenic mixture, optionally comprising adjuvant(s), to a patient suffering from nicotine or tobacco addiction or habituation.

Pharmacophore For Trail Induction

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US Patent:
20170107221, Apr 20, 2017
Filed:
Mar 30, 2015
Appl. No.:
15/126192
Inventors:
- La Jolla CA, US
Nicholas T. Jacob - San Diego CA, US
Jonathan W. Lockner - San Diego CA, US
International Classification:
C07D 471/14
Abstract:
There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein. The invention is directed, in various embodiments, to a compound and pharmaceutical composition comprising an effective amount of a compound capable of inducing expression of TRAIL gene in cells capable of expressing the TRAIL gene to produce the cytokine TRAIL.

Enantiopure Haptens For Nicotine Vaccine Development

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US Patent:
20170107275, Apr 20, 2017
Filed:
May 19, 2015
Appl. No.:
15/311322
Inventors:
- La Jolla CA, US
Jonathan W. LOCKNER - San Diego CA, US
International Classification:
C07K 16/16
C07D 401/04
Abstract:
The invention provides chiral haptens (−)-3′-AmNic and (−)-N4N for use in generating antibodies in a patient specific for (−)-nicotine. The haptens can be conjugated to suitable carrier proteins and administered as an antigenic mixture, optionally comprising adjuvant(s), to a patient suffering from nicotine or tobacco addiction or habituation.
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Jonathan W Lockner from San Diego, CA, age ~45 Get Report