Inventors:
Jonathan Bloom - Nyack NY
Kevin Curran - Nyack NY
Martin DiGrandi - Congers NY
Russell Dushin - Garrison NY
Thomas Jones - New City NY
Stanley Lang - Blauvent NY
Adma Ross - Suffern NY
Eugene A. Terefenko - Quakertown PA
Bryan OHara - Norwood NJ
Assignee:
American Home Products Corporation - Madison NJ
International Classification:
A61K 31341
Abstract:
Compounds of the formula: wherein R -R are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, âCN, âNO , âCO R , âCOR , âOR , âSR , âSOR , âSO R , âCONR R , âNR N(R R ), âN(R R ) or WâYâ(CH ) âZ provided that at least one of R -R is not hydrogen; or R and R or R and R , taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R and R are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R and R , taken together may form a 3 to 7 membered heterocycloalkyl; R -R are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R and R or R and R may be taken together to form aryl of 5 to 7 carbon atoms; provided that at least one of R is not hydrogen; W is O, NR , or is absent; Y is â(CO)â or â(CO )â, or is absent; Z is alkyl of 1 to 4 carbon atoms, âCN, âCO R , COR , âCONR R , âOCOR , âNR COR , âOCONR , âOR , âSR , âSOR , âSO R , SR6N(R7R8), âN(R R R) or phenyl; G is a monocyclic heteroaryl; X is a bond, âNH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6 useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.