John J Maloney

6827250, Dec 7, 2004

Jun 28, 2002

10/184259

Scott A. Uhland - Roslindale MA
Benjamin F. Polito - Cambridge MA
Stephen J. Herman - Andover MA
John M. Maloney - Cambridge MA

MicroCHIPS, Inc. - Bedford MA

B23K 106

2281101, 2281246, 21912164

Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; (2) providing a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; (3) positioning the hermetic sealing substrate over the reservoir openings and contacting said hermetic sealing materials of the primary substrate with said hermetic sealing materials of the hermetic sealing substrate; and (4) applying energy or a mechanical force to the contacted sealing materials effective to form a hermetic seal between the hermetic sealing substrate and the primary substrate to hermetically seal the reservoir openings.

6875208, Apr 5, 2005

May 31, 2002

10/159550

Michael J. Cima - Winchester MA, US
Nolan T. Flynn - Brookline MA, US
Scott A. Uhland - Roslindale MA, US
Zouhair Sbiaa - Malden MA, US
John M. Maloney - Cambridge MA, US

Massachusetts Institute of Technology - Cambridge MA

A61K009/22
A61M031/00
A61M037/00

6048901, 6048911, 604 9301

Microchip devices and methods of manufacture thereof are provided to increase the uniformity and reliability of active exposure and release of microchip reservoir contents. In one embodiment, the microchip device for the controlled release or exposure of molecules or secondary devices comprises: (1) a substrate having a plurality of reservoirs; (2) reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs; (3) reservoir caps positioned on the reservoirs over the reservoir contents; (4) electrical activation means for disintegrating the reservoir cap to initiate exposure or release of the reservoir contents in selected reservoirs; and (5) a current distribution means, a stress induction means, or both, operably engaged with or integrated into the reservoir cap, to enhance reservoir cap disintegration.

7413846, Aug 19, 2008

Nov 15, 2004

10/988667

John M. Maloney - Cambridge MA, US
Zouhair Sbiaa - Malden MA, US
Scott A. Uhland - Roslindale MA, US

MicroCHIPS, Inc. - Bedford MA

G03F 7/20

430320, 430322, 430323

Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e. g. , a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e. g. , gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.

7455667, Nov 25, 2008

Oct 26, 2005

11/259301

Scott A. Uhland - Roslindale MA, US
Benjamin F. Polito - Cambridge MA, US
John M. Maloney - Cambridge MA, US
Stephen J. Herman - Andover MA, US
Barry Y. Yomtov - Marblehead MA, US

MicroCHIPS, Inc. - Bedford MA

A61K 9/22

6048901, 604500

Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

7497846, Mar 3, 2009

Dec 6, 2004

11/005391

Scott A. Uhland - Roslindale MA, US
Benjamin F. Polito - Cambridge MA, US
Stephen J. Herman - Andover MA, US
John M. Maloney - Cambridge MA, US

MicroCHIPS, Inc. - Bedford MA

A61M 5/00
A61K 9/22

604173, 6048901

Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.

7497855, Mar 3, 2009

Sep 4, 2003

10/654761

Dennis Ausiello - Wellesley Hill MA, US
Stephen J. Herman - Andover MA, US
James H. Prescott - Cambridge MA, US
Scott A. Uhland - Roslindale MA, US
John M. Maloney - Cambridge MA, US
Benjamin F. Polito - Lebanon NH, US

MicroCHIPS, Inc. - Bedford MA

A61K 9/22

6048901

Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e. g. , two months, ten months, or more. ). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

7510551, Mar 31, 2009

Aug 15, 2003

10/641507

Scott A. Uhland - Roslindale MA, US
Benjamin F. Polito - Cambridge MA, US
John M. Maloney - Cambridge MA, US
Stephen J. Herman - Andover MA, US
Barry Y. Yomtov - Marblehead MA, US

MicroCHIPS, Inc. - Bedford MA

A61K 9/22

6048901

Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

7910151, Mar 22, 2011

Oct 27, 2005

11/260526

Scott A. Uhland - Roslindale MA, US
Benjamin F. Polito - Cambridge MA, US
John M. Maloney - Cambridge MA, US
Stephen J. Herman - Andover MA, US
Barry Y. Yomtov - Marblehead MA, US

MicroCHIPS, Inc. - Bedford MA

A61L 33/00

427 21, 6048901, 119650, 119654, 427 58

Devices and methods for the controlled release or exposure of reservoir contents, and methods of manufacture thereof, are provided. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. The controlled release system may be incorporated into an implantable drug delivery or biosensing device.