US Patent:
20110091496, Apr 21, 2011
Inventors:
Barney S. Graham - Rockville MD, US
Christopher B. Buck - Adelphi MD, US
Jeffrey N. Roberts - Rockville MD, US
Teresa R. Johnson - Gaithersburg MD, US
John Nicewonger - Ashburn VA, US
Rhonda Kines - Rockville MD, US
John T. Schiller - Kensington MD, US
International Classification:
A61K 39/12
A61K 39/00
A61K 39/235
A61K 39/155
A61K 39/21
C07H 21/00
C12N 15/63
A61P 31/12
A61P 37/00
US Classification:
4241921, 4241841, 4242041, 4242331, 4242291, 4242111, 4242081, 536 231, 4353201
Abstract:
The invention features immunogenic compositions and methods useful for eliciting an immune response. In preferred embodiments, papillomavirus or adenovirus vectors are used to elicit exceptionally potent antibody and T cells responses in disrupted epithelium. The methods are useful in preventing or treating a subject having a disease or an infection. In particular examples, the methods are useful for preventing or treating a viral infection.
