John T Mclane

20090215892, Aug 27, 2009

Oct 5, 2006

12/083141

Fatta B. Nahab - Gaithersburg MD, US
Mark Hallett - Bethesda MD, US
Jeff Serbin - New York City NY, US
John A. McLane - Warwick RI, US

A61K 31/045
A61K 31/23

514552, 514724

The invention features pharmaceutical formulations containing octanol and esters thereof. The pharmaceutical formulations are useful for the treatment of involuntary tremors.

20110112010, May 12, 2011

Feb 12, 2009

12/867702

Mark Hallett - Bethesda MD, US
John A. McLane - Warwick RI, US
Fatta B. Nahab - Gaithersburg MD, US

The Government of the United States of America, as represented by The National Institutes of Health - Rockville MD
Ariston Pharmaceuticals - Framingham MA

A61K 38/16
A61K 31/20
A61K 31/5513
A61K 31/23
A61K 31/7028
A61P 25/16
A61P 5/16
A61P 25/08
A61P 1/16

514 11, 514558, 514221, 514552, 514 25

The invention features pharmaceutical formulations containing octanoic acid or a salt or ester thereof. The pharmaceutical formulations are useful for the treatment of involuntary tremors.

53428331, Aug 30, 1994

Nov 22, 1993

8/155663

Thomas I. Doran - West Orange NJ
John A. McLane - New Haven CT
Masami Okabe - Nutley NJ
Michelangelo Scalone - Birsfelden, CH
Milan R. Uskokovic - Upper Montclair, NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C40100

514167

The invention is drawn to compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.

50735683, Dec 17, 1991

Nov 14, 1988

7/270980

Peter M. Wovkulich - Nutley NJ
Milan R. Uskokovic - Upper Montclair NJ
Ann Goldstein - Upper Montclair NJ
John A. McLane - West Haven CT

Hoffmann-La Roche Inc. - Nutley NJ

A61K 31365
C07D30910

514460

The invention relates to compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen or methyl; A is ##STR2## or A is ##STR3## wherein R. sub. 2 is lower alkyl; R. sub. 3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; and R. sub. 4 is hydrogen or methyl or the corresponding hydroxy acid of formula ##STR4## wherein A is ##STR5## or A is ##STR6## and R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 are as described above; or a pharmaceutically acceptable salt of said acid, a C. sub. 1-4 alkyl ester of said acid, an acetylamino-substituted-C. sub. 1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a. alpha. -monoglyceride of said acid. The compounds of formulas I and II are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis.

52005496, Apr 6, 1993

Sep 24, 1991

7/764641

Peter M. Wovkulich - Nutley NJ
Milan R. Uskokovic - Upper Montclair NJ
Ann Goldstein - Upper Montclair NJ
John A. McLane - West Haven CT

Hoffman-La Roche Inc. - Nutley NJ

C07C 6976
C07C 6963

560 61

The invention relates to compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen or methyl; ##STR2## wherein R. sub. 2 is lower alkyl; R. sub. 3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; and R. sub. 4 is hydrogen or methyl or the corresponding hydroxy acid of formula ##STR3## and R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 are as described above; or a pharmaceutically acceptable salt of said acid, a C. sub. 1-4 alkyl ester of said acid, an acetylamino-substituted-C. sub. 1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a. alpha. -monoglyceride of said acid. The compounds of formulas I and II are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis.

53939000, Feb 28, 1995

Jun 7, 1994

8/255012

Thomas I. Doran - West Orange NJ
John A. McLane - New Haven CT
Masami Okabe - Nutley NJ
Michelangelo Scalone - Birsfelden, CH
Milan R. Uskokovic - Upper Montclair NJ

Hoffmann-La Roche inc. - Nutley NJ

C07J 900

552505

The invention comprises compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases. The invention also includes a process for making these compounds and steroid intermediates of the process.

54280290, Jun 27, 1995

Nov 24, 1993

8/158068

Thomas I. Doran - West Orange NJ
Bernard M. Hennessy - Nutley NJ
John A. McLane - West Haven CT
Giacomo Pizzolato - Glen Ridge NJ
Farhad Sedarati - Wayne NJ
Milan R. Uskokovic - Upper Montclair NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C40100

514167

Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, X is H. sub. 2 or. dbd. CH. sub. 2, and the 23,24-double bond is E or Z, are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of tumors such as breast cancer, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne and seborrheic dermatitis.

57474788, May 5, 1998

Nov 23, 1994

8/344421

Thomas I. Doran - West Orange NJ
John Arthur McLane - New Haven CT

Hoffman-La Roche Inc. - Nutley NJ

A61K 3159

514167

Compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen are taught as useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.